TY  - BOOK
AU  - Pereira, Jan Paulo S., MD.
AU  - Abesamis, Robert Glen R., MD.
AU  - Esguerra, Mari Karr A., MD.
TI  - Undifferentiated uterine sarcoma : : a case report and review of diagnostic methods  
AV  - PATH 2020 0003 
PY  - 2020///
CY  - Fairview, Quezon City
PB  - Department of Pathology, FEU-NRMF
KW  - endometrial stromal sarcomas
KW  - immunohistochemistry
KW  - postmenopausal bleeding
N1  - Includes appendices and bibliographical references; RESDPLD
N2  -  Abstract:  Undifferentiated uterine sarcoma (UUS) is an extremely rare and notoriously aggressive form of endometrial stromal sarcomas (ESS) described to have high grade cytologic features without a specific type of differentiation. Outcome is very poor and its pathogenesis is currently unknown. Its low incidence limits its studies resulting to scarce amount of information both locally and internationally. It represents a diagnosis of exclusion making it both a clinical and a diagnostic dilemma. Therefore, arriving at an early diagnosis is extremely difficult. This case report aims to discuss UUS as a pathologic entity, review the utility of immunohistochemistry (IHC) when dealing with poorly differentiated uterine tumors, and briefly discuss molecular techniques used to diagnose this entity. We describe the case of a 69-year-old woman who presented with postmenopausal bleeding who subsequently underwent dilation and curettage. Her surgical pathology report revealed a poorly differentiated neoplasm with the following considerations but not limited to: high grade serous carcinoma, clear cell carcinoma, endometrial stromal sarcoma, and leiomyosarcoma. The patient, then, underwent extrafascial hysterectomy with bilateral salphingooophorectomy and bilateral lymph node dissection. Histomorphologic features revealed a poorly copy differentiated malignant tumor suggestive of underwent uterine sarcoma. An IHCpanel (ER, PR, cytokeratin, h-caldesmon, desmin, vimentin, CD10 and cyclin-D1) were them employed ultimately confirming the diagnosis of undifferentiated uterine sarcoma by eliminating other malignant conditions that mimic its histomorphologic gestures. By reporting this case, additional information will be added up to the already limited amount of studies found in the literature.
ER  -