The Use of plant-based alternative in vitro anticoagulant in diagnostic laboratory : a systematic review /
Al Daniel S. Abagatnan, Samantha Nicole P. Allera, Joshua Christian L. Estanislao, Jelline Mae A. Estipular, Kim Princes R. San Diego, Gil Clinton S. Tesorero; Richard Rupert T. Vicencio.
- Fairview, Quezon City : School of Medical Technology, FEU-NRMF, 2022.
- 70 pages: illustrations, tables, photos; 28 cm.
Includes appendices and bibliographical references.
Abstract: A routine examinations to evaluate for abnormalities in health usually includes laboratory tests. Anticoagulants are commonly used to supress the coagulation process in vitro and in vivo. Furthermore, blood collection tibes used in clinical laboratories contain anticoagulants to preserve the blood samples intheir fluid state. Hence, this study aimed to determine the use of plant-based alternative in vitro anticoagulants in diagnostic laboratories. This study focused on the anticoagulant capability, chemical components of the plant-derived in vitro anticoagulants, and their effects on the blood cells. The researchers gathered data from different databases such as PubMed, Google Scholar, ResearchGate and EBSCohost. The most important criteria of the journal articles included must have PT and aPTT results. A total of 46 plants and 61 extracted major chemical constituents are involved in the study. The highest aPTT and PT results were found in Thymus atlanticus and Thymus zygis. It revealed that flavonoids are the most common chemical constituents in the study. Chemical constituents may or may not affect the blood cells. In the study, The researcher found out that the most common toxic effect of some chemical constituents is the alteration of blood cell count. The most anticoagulant activity was seen in Thymus atlanticus and Thymus zygis, thus, study concluded that to be the most efficient plant-based alternative in vitro anticoagulants.