TY  - BOOK
AU  - Ludovica, Joana Jo R., MD.
TI  - Lymphocyte immunotherapy in recurrent pregnancy loss : : a case report / 
AV  - OB 2021 0006 
PY  - 2021///
CY  - Fairview, Quezon City
PB  - Department of Obstetrics and Gynecology, FEU-NRMF
KW  - recurrent pregnancy loss
KW  - lymphocyte immunotherapy
KW  - immune tolerance
KW  - alloimmune pregnancy
N1  - Includes appendices and bibliographical references; RESDOG
N2  - Abstract:  Recurrent Pregnancy Loss (RPL) is a multifactorial condition defined as having two or more consecutive pregnancy losses. Investigation of the well-established causes is warranted to increase the chance of subsequent good pregnancy outcome. However, 50% of the RPL cases remains unexplained. Pregnancy involves shift in the immunologic response to initiate immune tolerance. Deviation from the normal immune tolerance response may lead to pregnancy failure and is the proposed mechanism of unexplained recurrent pregnancy loss. Lymphocyte immunotherapy, which involves transfusion of paternal leukocytes to the maternal peripheral blood to induce an immune response creating a conducive environment for pregnancy maintenance, is a proposed therapy for unexplained RPL.  This is a case report of a 40 year old, Gravida 7 Para 1, with Recurrent Pregnancy Loss, with no known genetic, uterine, and coagulation anomalies who initially underwent assisted reproductive techniques with Intrauterine Insemination and eventually underwent 4 cycles of Lymphocyte Immunotheraphy, and was able to conceive and deliver at term
ER  -