The Diagnosis accuracy of rapid antigen test in detecting COVID-19 mate-analysis : meta-analysis /
Ma. Marinela N. Meracap, Smilla P. Montera, Josef Carlyle A. Nery, Patrick Lanz D. Padilla, Christine Mae D. Pajado, Iesous John Andrei M. Pineda, Maria Laica B. Prado, Raniela P. Sampang, Nikka Angelique T. Sison, Jill Anne R. So, Jefrrey Ralph P. Tan and Arnold Bill V. Unidad.
- Fairview, Quezon City: Department of Community and Family Medicine, FEU-NRMF, 2022.
- 51 pages: illustrations, tables; 28 cm.
Includes bibliographical references.
Abstract: Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) provides a reliable diagnosis of COVID-19 infection which is why it is regarded as the gold standard for viral detection. Utilization of this test takes several hours for the results to be retrieved. Employing of Covid-19 Rapid Antigen Tests Rapid Antigen Tests (RATs) for detection and diagnosis permits a shortened turn-around time as its utilization does not need any specialized equipment and results can be garnered within thirty minutes. This study assessed RATs' diagnositic accuracy for the detection of COVID-19. The study includes diagnostic cross-sectional studies consisting of resources conducted from 2020 to 2022. Evaluation was performed based on the objective of the study and had to meet the criteria for inclusion. With the COVID-19 RT-PCR as a reference standard, those who were qualified in the inclusion criteria were examined for the accuracy, specificity, and sensitivity of the RAT for diagnosing SARS-CoV-2. Literature search was conducted using Cochrane central, Medline, Embase, Herdin and other various databases. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool was used to evaluate the applicability of included students and risk of bias in the study. Analysis of studies included were conducted through RevMan 5.4 and MetaDisc 1.4. Twenty four articles were collected from various electronic databases and only seven articles were included depending upon the entirely of the extracted data. The meta-analysis for antigen testing generated an overall pooled sensitivity, specificity and DOR of 0.84 (95% CI, 0.83-0.85), 0.99 (95% CI, 0.99) and 401.85 (95% CI, 202.24-798.47). Moreover, the area under the curve of SROC was 0.98.
Thesis - Department of Community & Family Medicine