TY  - BOOK
AU  - Dizon,Andrea Kirstie D.
AU  - Duban, Monica P.
AU  - Echalico, Mavyll H.
AU  - Edralin, Ma. Bettina Lean S.
AU  - Garcia, Frances Almari S.
AU  - Libao, Mhel Abigail S.
AU  - Luna, Ma. Clarisse Z.
AU  - Miguel, Liam Mario L.
AU  - Montano, Jansen Carlos C.
AU  - Remorque, Arvin Real M.
AU  - Sanchez, Mica Trisha M
AU  - Zafra, Carl Stephen N.
TI  - Current and latest human antemortem diagnostic technologies detecting rabies virus: a systematic review / : [author]: Dizon, Andrea Kirstie D. Duban, Monica P. Echalico, Mavyll H. Edralin, Ma. Bettina Lean S. Garcia, Frances Almari S. Libao, Mhel Abigail S. Luna, Ma. Clarisse Z. Miguel, Liam Mario L. Montano, Jansen Carlos C. Remorque, Arvin Real M. Sanchez, Mica Trisha M. Zafra, Carl Stephen N
AV  - MT 2023 0011 c.1 
PY  - 2023///
CY  - Quezon City, Philippines
PB  - FEU-Dr. Nicanor Reyes Medical Foundation Institute of Medicine
N1  - Includes Appendix; bri'oot; THMT
N2  - ABSTRACT:  Rabies virus is a prevalent disease in the Philippines; however, it is preventable through proper antemortem diagnosis. This systematic review aimed at determining the accuracy of different testing methods for rabies using credible sources (e.g., PubMed, ResearchGate, and Google Scholar). Both sensitivities and specificities of the various diagnostic tools done in humans were compared. Journals written in languages other than English, required payment for full-text, tests done on postmortem only, and species other than humans were excluded. Keywords were used as the search strategy when utilizing databases to gather each journal. The target sources included journals that tackle tests like PCR, Direct Fluorescence Antibody Tests, Dot Blot Enzyme Immunoassay, Rapid Fluorescence Focus Inhibition Tests, and Rabies Tissue Culture Infection Tests. As a result, the study proved that molecular methods were more effective than FAT for antemortem diagnosis of rabies. Furthermore, the study also highlighted the need for additional resources to make these methods more accessible in resource-limited settings. Amongst the different testing methods, Polymerase Chain Reaction (PCR) and other variants were the most reliable and widely used regardless of the variations in samples used. Majority of these variants showed 100% in both specificity and sensitivity which were considered unquestionably high compared to FAT, Dot Immunobinding Assay (DIA), and other diagnostic methods that showed sensitivities and specificities below 100%. Therefore, a molecular approach in antemortem diagnosis of rabies showed great importance.  Keywords: antemortem, diagnostic tools, rabies, rabies detection, RT-PCR
ER  -