The role of high sensitivity c-reactive protein as a predictor of clinical outcome among admitted adult covid-19 patients. /   [Author]: Pereira, Jan Paulo S., Atibagos, Jr., Florido A., Esguerra, Mari Karr A.  

 - Fairview, Quezon City:  Department of Pathology, FEU-NRMF,  2023 
 -  ( in folder )  with flash drive (soft copy) 
<br/><br/>Includes bibliographical references. 
<br/><br/> ABSTRACT:<br/>Background: Elevated levels of interleukin-6 (IL-6) and the presence of cytokine storm is associated with a poorer outcome in COVID-19. IL-6 is the primary cytokine involved in the production of c-reactive protein (CRP) which is uniformly increased in cytokine storm. CRP also shows correlation with the severity of COVID-19 making it a promising predictor of clinical outcomes. It can be measured using monoclonal antibody-based test referred to as high sensitivity C-reactive protein (HS-CRP). This method has superior assay precision and accuracy in comparison to conventional means of CRP measurement. Objectives: To determine the role of HS-CRP as a predictor of clinical outcomes among admitted adult COVID-19 patients. Subjects and Methods: This is a retrospective cohort study. Randomly selected medical records of 110 adult COVID-19 patients who were admitted in a tertiary hospital were used. HS-CRP measurement was used as a predictor of outcomes which were divided into goad outcome (improvement and recovery) and poor outcome (deterioration and death).<br/>Results: Of the 110 patients, 62 were males while 48 were females. The age ranges from 22 to 95 years old with a median age of 60 years old. Among these patients, 85 were discharged while 25 died. As for the HS-CRP measurement, patients with > 20 final HS-CRP are 7.667 times more likely to expire compared to patients with < 20 final HS-CRP. It was observed that for every 1.0 unit increase in patients first HS-CRP, the odds of mortality also increase by 0.81%. there will also be a 1.21% increase in the odds of mortality for every 1.0 unit increase in patients final HS-CRP.<br/>Conclusion: Our study supports that an HS-CRP value-20.00 mg/L be used a predictor of poor outcome, particularly death. <br/>Keywords: COVIS-19, demographics, high sensitivity C-reactive protein, COVID-19 predictor of outcome, retrospective cohort study.<br/><br/><br/><br/> 
<br/><br/> Department of Pathology & Laboratory Diagnosis  Research - Department of Pathology & Laboratory Diagnosis 
<br/><br/><label>LC Class. No.: </label>PATH 2023 0001