A descriptive study on the incidence of autoimmune diseases in patients who had sars-cov-2 infection./   [Principal Investigator]: Yu, Kimberly S.  

 - Fairview, Quezon City:  Department of Medicine, FEU-NRMF,  2023 
 -  (in folder)  with flash drive (soft copy) 
<br/><br/>Includes bibliographical references. 
<br/><br/> ABSTRACT:<br/>Background: The emergence of the Severe Acute Respiratory Corona Virus 2 Syndrome (SARS-CoV-2) or COVID-19 in December 2019 has raised concerns about its potential to trigger autoimmune diseases. Previous researches have shown that viral infections can lead to autoimmune diseases through molecular mimicry; and SARS-CoV-2 has been found to disrupt normal antiviral immunity, potentially leading to autoimmune responses.<br/>Objectives: This study aims to investigate the prevalence of autoimmune diseases in patients following COVID-19 infection and vaccination, with a focus on the differences in prevalence between the two groups. This study also aims to explore the potential<br/>mechanisms by which SARS-CoV-2 may trigger autoimmune diseases.<br/>Methodology: A retrospective cohort study was conducted at FEU-NRMF Medical Center, involving adult patients diagnosed with autoimmune diseases post COVID-19 infection and vaccination from January 2022 to September 2023. Data from patient<br/>records were analyzed using univariate descriptive statistics to explore differences in prevalence and demographics between the two groups.<br/>Results: The study found that females were more prone to autoimmune diseases in both post COVID-19 infection and post COVID-19 vaccination. Psoriatic Arthritis and Systemic Lupus Erythematosus were prevalent autoimmune diseases in post COVID-19 infection, while Systemic Lupus Erythematosus and Rheumatoid Arthritis were prevalent in post COVID-19 vaccination. Additionally, the study revealed a higher prevalence of autoimmune diseases in post COVID-19 vaccination compared to post COVID-19<br/>infection. The findings suggest a link between SARS-CoV-2 infection and vaccination with the development of autoimmune diseases, highlighting the need for further research and vigilance in monitoring autoimmune responses following COVID-19. Additionally, the study underscores the importance of considering gender-specific differences in autoimmune disease prevalence.<br/>Keywords: SARS-CoV-2, COVID-19, autoimmune diseases, vaccination, prevalence<br/>gender differences, molecular mimicry, immune response.<br/> 
<br/><br/> Department of Medicine  Research - Department of Medicine 
<br/><br/><label>LC Class. No.: </label>MED 2023 0008