TY  - BOOK
AU  - Bonoan, Sara A., MD.
TI  - Malignant hyperthermia: a case report 
AV  - ANES 2010 0004 
PY  - 2010///
CY  - Fairview, Quezon City
PB  - Department of Anesthesiology, FEU-NRMF
KW  - malignant hyperthermia
N1  - Includes appendices and bibliographical references; RESDA
N2  - Abstract;  Malignant htperthermia (MH) is a rare pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as isoflurane and depolarizing neuromuscular blocking agent, succinycholine. It is said to be to a defective calcium channel located in the sarcoplasmic reticulum membrane called the ryanodine receptor.\  Presented is a case of a 55 year old male who underwent direct laryngoscopy under general anesthesia in which the classic signs of MH were observed such as hyperthermia to a marked degree, tachycardia, tachypnea, increased end-tidal carbon-dioxide, acidosis, muscle rigidity and rhaabdomyolysis. These pathophysiologic changes of MH could lead to life-threatening complications like renal failure from rhabdomyolysis and disseminated intravascular coagulation (DIC) which were seen in our patient, hence the demise despite resuscitative measures and treatment
ER  -