TY  - BOOK
AU  - Concepcion, Jennifer C.
AU  - Calingayan, Caroline M.
AU  - Muhi, Edzel L.
AU  - Rapinan, Derliefe R.
AU  - Sia, Aileen Y.
AU  - Tajon, Claire M.
TI  - COMPARATIVE STUDY ON THE EFFECTS OF TOPICALLY ADMINISTERED ACETAZOLAMIDE WITH 0.9% NSS AND TOPICAL ACETAZOLAMIDE IN HPM IN THE INTRAOCULAR PRESSURE OF ALBINO RABBITS
AV  - MPHAR20000010 
PY  - 2000///
CY  - QUEZON CITY
PB  - FEU-NRMF
N1  - farmakoloji
N2  - ABSTRACT: Hydroxypropyl methylcellulose, a known opthalmic solution vehicle, is combined with acetazolamide, an accepted intraocular lowering agent, to make a 0.8% solution and instilled into the conjunctival  cul-de-sac  of rabbit`s eyes.  Topical administration of the 0.8% acetazolamide - HPM  solution after the oral induction of water resulted to a slow but sustained in the artificially induced rise in the intraocular pressure of rabbit`s eyes after 30, 60, and 120 minutes following waterloading in comparison to eyes treated with acetazolamide in 0.9%  NSS .  In the eyes treated with 0.9% acetazolamide - NSS, the decrease in intraocular pressure was found to be immediate but short in duration when measured after 30, 60, and 120 minutes.  No conjunctival nor corneal irritation as well as any observable side effects were noted.
ER  -