TY  - BOOK
AU  - Bernardo, Bernadette
AU  - Fababier, Richard
AU  - Ferry, Edgar Allen
AU  - Galman, Lanie
AU  - Ilo, Khristine
AU  - Mong, Abigail
AU  - Pablo, Haydee
AU  - Santiago, Maribel
AU  - Usita Julius
TI  - THE ANTIMUTAGENIC EFFECT OF SWEET POTATO  (IPOMOEA BATATAS) ON MITOMYCIN-C INDUCED MALE ALBINO RAT
AV  - THE M-PHAR 2001 0021 
PY  - 2001///
N1  - farmakoloji
N2  - Cancer is one of the fatal diseases known to man. Economic status, culture, genetics and lifestyle are just some of the multifactorial contributors that come into play in the causation of the disease.                                                                                                                                   Seeing the need for cheap and alternative or adjunct to current therapy, this study aims to demonstrate the antimutagenic effect of Ipomoea batatas  (kamote)  on Mitomycin-C-induced tats.                                                                                                                                In the experiment, 15 male albino rats were divided into 3 groups with 5 rats each After a week of acclimatization, Group 1 as the baseline negative was given NSS only, Group 2 was given Mitomycin-CC, and Group 3 was given Mitomycin-C and kamote extract After 3 days, the animals were sacrificed.  The femurs were isolated and the bone marrow aspirated through syringe.  The aspirate was smeared, air dried, stained, and then viewed under compound light microscope.  The number of micronuclei was counted per 1,000 rbcs/slide as a measures of mutagenic effect.                                                                             The values obtained were averaged and analyzed using Analysis of Variance (ANOVA) at F-distribution and Scheffe`s test with a confidence interval of 95%.  The result showed that was a significant different between the three groups.  There was a significant difference between the frequency of micronuclei in the rbc`s of the group of rats induced with Mitomycin-C and then given kamote extract than those of the group of rats from which kamote extract was witheld, with group 3 mice showing considerably less micronuclei.  With the defined parameters for antimutagenicity, plus the demonstrated decrease in micronuclei count in group 3 rats, the researchers concluded the kamote extract as antimutagenic in Mitomycin-C-induced rats
ER  -