TY  - BOOK
AU  - Capino, Andrea J.
AU  - Gammad, Cheryl Erika C.
AU  - Lozada, Maria Imelda J.
AU  - Montevirgen, Mary Richelle C.
AU  - Pineda, Clarissa S.
AU  - Sison, Cherry V.
AU  - Tamayo, Marygrace D.
AU  - Villena Kristoffer Y.
TI  - A COMPARATIVE STUDY OF THE CRUDE EXTRACTS OF LAGERSTROEMIA SPECIOSA  (BANABA)  AND MOMORDICA CHARANTIA  (AMPALAYA)  IN LOWERING BLOOD GLUCOSE OF HYPERGLYCEMIC MICE
AV  - MPHAR20030002 
PY  - 2003///
CY  - Quezon City
PB  - FEU-NRMF
N1  - farmakoloji
N2  - ABSTRACT: Lagerstromia speciosa  (banaba) and Momordica charantia  ( Ampalaya ) are available in the market as food supplements and herbal teas claiming hypoglycemic activity.  In an effort to establish and compare the hypoglycemic activity of Momordica charantia  (Ampalaya) and Lagerstromia speciosa  (Banaba )  in validated models of hyperglycemic  Swiss mice.  the extract from their leaves was studied.  A standard drug, Gliclazide was also used as the base of comparison if both extracts were really effective or not. A total of 60 mice were used. grouped into four groups with equal number of male and female.  Group 1 was given glucose and NSS and served as the control group, group 2 glucose and ampalaya extract, group 3 with glucose and banaba and group 4 with glucose and the standard drug.   The type of hypoglycemic substances along with the Gliclazide and Control group  (Glucose = NSS) are indicated with different time  (0 hr., 30 mins., 1 hr., 1 1/2hrs., 2 1/2 hrs.) dependent effects.  At  0  hr.  the blood glucose levels of Swiss mice which presented as hypoglycemia were 95=31, 82.5=28.5, 96=23, and 82=25 for Ampalaya extract, Banaba extract, Gliclazide, and Glucose, respectively.  A dosage of 2 g/kg of Glucose was injected intraperitoneally to the Swiss mice at  0  hr.  which made them hyperglycemic when their blood glucose level was taken after thirty mins.  with results of 115.5=35.5.5,  170.5=77.5,  142.5=45.5,  129=27.  The swiss mice were then administered with 150 mg/kg of Ampalaya extract,  250/100g of Banaba extract, and 200 mg/100g of Gliclazide.  After 2 hrs., all blood glucose concentrations went down with results of 99.5=35.5, 151.5=71.5, 75.5=13.4,  118.5=35.5.  This suggests that administered Ampalaya extracts produce a lower glucose concentration as to that of Banaba extracts which was compared to Gliclazide as a standard drug that seved as a positive control
ER  -