TY  - BOOK
AU  - Section B
AU  - Bringas, Mari-Ann B., MD.
AU  - Viiran, Dolores V., MD.
TI  - Prevalence of zinc deficiency and its relationship with glycosylated hemoglobin levels among type II diabetes mellitus patients / 
AV  - M BIO 2014 0002 
PY  - 2014///
CY  - Fairview, Quezon City
PB  - Department of Biochemistry, FEU-NRMF
KW  - prevalence
KW  - zinc deficiency
KW  - diabetes
N1  - Includes appendices and bibliographical references; THDBN
N2  - Abstract:  Diabetes mellitus is a chronic disease considered as a global problem. Decreased zinc (Zn) levels, which affects the ability of the islet cell to produce and secrete insulin, might compound the problem associated with type 2 diabetes. Zinc promotes different biochemical reactions in the body and is being investigated to aide in the improvement of management strategies for various diseases such as DM.  To determine the prevalence of zinc deficiency and to correlate serum Zn with HbA1c levels of Type II Diabetic patients.  Serum Zinc and HbA1c levels were determined on blood samples from 101 patients in FEU-NRMF and VMMC. General information was acquired via interview and anthropometric assessment was also conducted. Zinc deficiency was summarized using percentages or proportion. Serum zinc and glycosylated hemoglobin levels (HbA1c) were summarized using mean and standard deviation. Linear regression, T-test, ROC characterization and Chi-square was utilized to correlate serum zinc levels with HbA1c. Level of significance was set at ɑ= 0.05  The prevalence of ZD in the sample population was 5.9%. Linear Regression (F=0.6853 > ɑ = 0.05) showed negative correlation between HbA1c and Zn levels. T-test revealed no significant difference between Zn levels of controlled and uncontrolled DM (P=value = 0.645,> ɑ = 0.05). ROC obtained cut off serum zinc levels 70 µg/dl or higher predicted good control of DM, although statistically in significant (p > ɑ = 0.05).  Prevalence of ZD was low among T2DM patients. However, there was occurrence of more uncontrolled DM than controlled DM among patients with ZD. Inverse relationship was observed between serum Zn levels and HbA1c levels. Normal to high Zinc levels > 70 µg/dL predicted good control of Zinc levels. The trend however, is statistically insignificant.
ER  -