TY  - BOOK
AU  - Section A2
TI  - Preliminary study on the effect of lactobacillus fermentum on the blood cholesterol level among young adults
AV  - M BIO 2006 0003 
PY  - 2006///
CY  - Fairview, Quezon City
PB  - Department of Biochemistry, FEU-NRMF
N1  - Includes appendices and bibliographical references; THDBN
N2  - Abstract:  The variability in the baseline cholesterol levels of 30 young adults was determined.  Values ranged from 1.85 - 5.30 mmol / Liter. After a week under a high cholesterol diet, cholesterol levels of the young adults significantly increased (p<0.05). Values ranged from 2.61 - 6.55 mmol / Liter. Variability in the cholesterol levels is attributed to an each individuals unique biochemistry, physiology, lifestyle and even genetics. Fischer's Extract Test values conferred the responsive behavior of cholesterol level (increase or decrease) to the both the Probiotic drug and the placebo. The placebo had a greater effect on the behavior of cholesterol level on the 1st and 3rd dosage period (1 capsule / day and 3 capsules/ day, respectively), (1 - tailed Left-Sided Pr < = F 0.1648 and 1- Tailed Left Sided Pr < = F 0.1362, respectively). Probiotic effect on decreasing cholesterol level was significant (p < 0.25) at the 2nd dosage period (2 capsules/ day), (1- tailed Right-sided Pr <= F 0.02311). This confirms the cholesterol-lowering property of the Probiotic , which may be attributed to the bile-acid deconjugating property of the Lactobacillus fermentum. The Odds Ratio showed the taking the Probiotic drug twice a day more effective in lowering the cholesterol level (2.2857 with 95% confidence interval- 1.3519, 10.0185). Odds ratio for the 1st and 3rd dosage period showed the greater effect of the placebo, though only half as potent as compared to the cholesterol- lowering activity during 2nd dosage period (0.1964 with 95% confidence interval - 0.0191, 2.0174 and 0.333 with confidence interval - 0.0751, 1.4787, respectively). These further confer the functionality of the Probiotic drug, especially at two capsules per day, not only in improving the intestinal environment for better absorption, but also in lowering blood cholesterol levels. Furthermore, Probiotics can potentially decrease the risk of having cholesterol-related diseases. Several factors such as individual differences in biochemistry, physiology, compliance may contribute to the variable behavior of cholesterol levels in response to both the placebo and Probiotics.
ER  -