000			02911nam a22003497a 4500
999			_c10511 _d10511
001			PH 2017 0012
003			PILC
005			20240720152955.0
008			180320b xxu||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _erda
041			_aenglish
050			_aPH 2017 0012
245			_aStability of fluconazole solution as an ophthalmic preparation / _cMari Addylaine M. Reyes, Jonah Jane R. Sedano, Klarisse Pauline M. Taaca, Ruby Jean R. Tumala and Jimrouse Clarisse C. Vinluan.
260			_aFairview, Quezon City: _bSchool of Pharmacy, FEU-NRMF, _c2017.
300			_a72 pages: _billustrations, tables, photos; _c28 cm. + _eCD (soft copy)
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes appendices and bibliographical references.
520			_aAbstract: Fungal keratitis is an infection of the cornea. It can cause blindness if not treated and in some cases, treatment cannot restore vision. In these cases, permanent vision impairment or blindness may occur. One treatment for fungal keratitis is fluconazole. In the market, fluconazole is available in oral and intravenous preparations only and there is no ophthalmic preparation available yet. Natamycin 5% w/v is the only ophthalmic preparation registered to the FDA. In some countries in the United States of America, fluconazole is extemporaneously prepared. And there are studies stating the intra-corneal penetration of fluconazole making it a possible formulation for an ophthalmic solution. This led the researchers to study its stability for 30-day period under 40°C ± 2°C. As in-use stability testing (14-day stability)was also performed simulating the usage of the patient in his home under room temperature. Fluconazole (Diflucan) 2 mg/ml was used and was transferred into different vials containing 10 ml each. The purity, pH and viscosity of the solution were determined on day 0 and day 30 of storage for the 30-day stability test. And for the in-use stability test, the purity and pH was determined on day 0, 1, 5, 9 and 14 while the viscosity was determined on day 0, 5, 9 and 14 storage. The researchers therefore conclude that both for the 30-day and 14-stability test, the pH of the solution was within the acceptable range of 4.5 to 11.5, while the assay and viscosity results showed a decreasing value over time because of the solution being subjected to high temperature which enhanced the degradation of the preparation,
521			_aTHPH
650			_astability
650			_ain-use stability
650			_afluconazole
650			_afungal keratitis
700			_aReyes, Mari Addylaine M. _eauthor
700			_aSedano, Jonah Jane R. _eauthor
700			_aTaaca, Klarisse Pauline M. _eauthor
700			_aTumala, Ruby Jean R. _eauthor
700			_aVinluan, Jimrouse Clarisse C. _eauthor
942			_2lcc _cRU