000			02963nam a22003137a 4500
999			_c12011 _d12011
001			PATH 2020 0003
003			PILC
005			20240720153216.0
008			211022b xxu||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _erda
041			_aenglish
050			_aPATH 2020 0003
245			_aUndifferentiated uterine sarcoma : _ba case report and review of diagnostic methods / _cJan Paulo S. Pereira, Robert Glen R. Abesamis and Mari Karr A. Esguerra.
260			_aFairview, Quezon City: _bDepartment of Pathology, FEU-NRMF, _c2020.
300			_billustrations, tables, photos; _c(in folder) _ewith flash drive (soft copy).
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes appendices and bibliographical references.
520			_a Abstract: Undifferentiated uterine sarcoma (UUS) is an extremely rare and notoriously aggressive form of endometrial stromal sarcomas (ESS) described to have high grade cytologic features without a specific type of differentiation. Outcome is very poor and its pathogenesis is currently unknown. Its low incidence limits its studies resulting to scarce amount of information both locally and internationally. It represents a diagnosis of exclusion making it both a clinical and a diagnostic dilemma. Therefore, arriving at an early diagnosis is extremely difficult. This case report aims to discuss UUS as a pathologic entity, review the utility of immunohistochemistry (IHC) when dealing with poorly differentiated uterine tumors, and briefly discuss molecular techniques used to diagnose this entity. We describe the case of a 69-year-old woman who presented with postmenopausal bleeding who subsequently underwent dilation and curettage. Her surgical pathology report revealed a poorly differentiated neoplasm with the following considerations but not limited to: high grade serous carcinoma, clear cell carcinoma, endometrial stromal sarcoma, and leiomyosarcoma. The patient, then, underwent extrafascial hysterectomy with bilateral salphingooophorectomy and bilateral lymph node dissection. Histomorphologic features revealed a poorly copy differentiated malignant tumor suggestive of underwent uterine sarcoma. An IHCpanel (ER, PR, cytokeratin, h-caldesmon, desmin, vimentin, CD10 and cyclin-D1) were them employed ultimately confirming the diagnosis of undifferentiated uterine sarcoma by eliminating other malignant conditions that mimic its histomorphologic gestures. By reporting this case, additional information will be added up to the already limited amount of studies found in the literature.
521			_aRESDPLD
650			_aendometrial stromal sarcomas
650			_aimmunohistochemistry
650			_apostmenopausal bleeding
700			_aPereira, Jan Paulo S., MD. _eauthor
700			_aAbesamis, Robert Glen R., MD. _eauthor
700			_aEsguerra, Mari Karr A., MD. _eauthor
942			_2lcc _cRU