000			03415nam a22003497a 4500
999			_c12281 _d12281
001			OPH 2021 0002
003			PILC
005			20240720153243.0
008			220427b xxu||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _erda
041			_aenglish
050			_aOPH 2021 0002
245			_aA Systematic review and meta-analysis on the long-term efficacy and safety of micro pulse diode laser transscleral cyclophotocoagulation in patients with glaucoma / _cRudolf Christian F. Palma; Julia Mercedes C. Villalva; Manolito R. Reyes.
260			_aFairview, Quezon City: _bDepartment of Ophthalmology, FEU-NRMF, _c2021.
300			_a40 pages: _billustrations, tables; _c(in folder) + _ewith flash drive (soft copy).
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes appendices
520			_aAbstract: This systematic review and meta-analysis aim to review available information that addresses the question regarding the long-term efficacy in intraocular pressure (IOP) control and reduction, and the complication rates of Micropulse Transscleral Cyclophotocoagulation in patients with glaucoma. CENTRAL, PubMed and Google Scholar were used as data sources. Studies that include glaucoma patients who underwent MP-TSCPC with one year or more post-operative follow-up with data on pre-and post-operative IOP and complications were considered. NHLBI Quality Assessment Tool was used for the included studies. The treatment effect measures were (1) weighted mean difference (WMD) for the IOP reduction and, (2) proportions for the complication rate. Outcome measures were reported with a 95% confidence interval (CI) and P < 0.05 was considered statistically significant. Analysis was performed using Microsoft Excel and Open Meta Analysis software. In this systematic review, thirteen studies were included in total. Ten were case series, two were observational cohorts, and one randomized controlled trial. Risk of bias studies showed low to moderate risk among the included studies. In random effects model the pooled weighted mean difference was -13.649 (95% CI: {-16.350 - -10. 948], P < 0.001) showing statistically significant reduction in IOP after MP-TSCPC. Pooled proportion risk for complications was 0.418 (95% CI: [0.174 - 0.663], P < 0.001). And among the most common of these complications are the post- operative inflammation at 0.257 (95% CI: [0.094 - 0.420], P = 0.002) and post-operative pain at 0.039 (95% CI: [0.017 - 0.061], P <0.001). There is lack of high-quality evidence on the subject as only one RCT was retrieved. Our findings are based, therefore, mostly on case series and non-controlled observational studies. Our results showed that MP-TSCPC has good efficacy in reducing and controlling IOP after a year post-operatively. It is also safe with low risk of complications with the more common complications being post-operative inflammation and post-operative pain.
521			_aRESDOP
650			_aglaucoma
650			_aintraocular pressure
650			_2complications
650			_amicropulse transscleral cyclophotocoagulation
650			_ameta-analysis
650			_asystematic review
700			_aPalma, Rudolf Christian F., MD. _eauthor
700			_aVillalva, Julia Mercedes C., MD. _eauthor
700			_aReyes, Manolito R., MD. _eauthor
942			_2lcc _cRU