000			03015nam a22002657a 4500
001			R000749
003			PILC
005			20240807104850.0
008			240807b |||||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _drda
041			_aeng
050			_aMED 2023 0008
245			_aA descriptive study on the incidence of autoimmune diseases in patients who had sars-cov-2 infection./ _b[Principal Investigator]: Yu, Kimberly S.
260			_aFairview, Quezon City: _bDepartment of Medicine, FEU-NRMF, _c2023
300			_c(in folder) _ewith flash drive (soft copy)
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references.
520			_aABSTRACT: Background: The emergence of the Severe Acute Respiratory Corona Virus 2 Syndrome (SARS-CoV-2) or COVID-19 in December 2019 has raised concerns about its potential to trigger autoimmune diseases. Previous researches have shown that viral infections can lead to autoimmune diseases through molecular mimicry; and SARS-CoV-2 has been found to disrupt normal antiviral immunity, potentially leading to autoimmune responses. Objectives: This study aims to investigate the prevalence of autoimmune diseases in patients following COVID-19 infection and vaccination, with a focus on the differences in prevalence between the two groups. This study also aims to explore the potential mechanisms by which SARS-CoV-2 may trigger autoimmune diseases. Methodology: A retrospective cohort study was conducted at FEU-NRMF Medical Center, involving adult patients diagnosed with autoimmune diseases post COVID-19 infection and vaccination from January 2022 to September 2023. Data from patient records were analyzed using univariate descriptive statistics to explore differences in prevalence and demographics between the two groups. Results: The study found that females were more prone to autoimmune diseases in both post COVID-19 infection and post COVID-19 vaccination. Psoriatic Arthritis and Systemic Lupus Erythematosus were prevalent autoimmune diseases in post COVID-19 infection, while Systemic Lupus Erythematosus and Rheumatoid Arthritis were prevalent in post COVID-19 vaccination. Additionally, the study revealed a higher prevalence of autoimmune diseases in post COVID-19 vaccination compared to post COVID-19 infection. The findings suggest a link between SARS-CoV-2 infection and vaccination with the development of autoimmune diseases, highlighting the need for further research and vigilance in monitoring autoimmune responses following COVID-19. Additionally, the study underscores the importance of considering gender-specific differences in autoimmune disease prevalence. Keywords: SARS-CoV-2, COVID-19, autoimmune diseases, vaccination, prevalence gender differences, molecular mimicry, immune response.
521			_arefooah _aRESDM
700			_aYu, Kimberly S. _ePrincipal Investigator
856			_21
942			_2lcc _cRE
999			_c12997 _d12997