000			03595nam a22003617a 4500
001			T002874
003			PILC
005			20241028140417.0
008			241028b |||||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _drda
050			_aMT 2024 0023 c.1
100	1		_aAngon, Rosh Matthew R _eauthor
245	0	1	_a Accuracy of the biomarkers amyloid p-protein (ap), total tau (t-tau), phosphorylated tau (p-tau), and neurofilament chain (NFL) in diagnosing ALZHEIMER'S disease: a systematic review _b[author]: Angon, Rosh Matthew R., Baetiong, Kai Irish D., Del Rosario, Hannah Sophia D.S., Maningding, Jereez Xean J. Manuel, Dainty Jewel C., Mercado, Romulo III D., Quizana, Jezzel Mae G., Santiago, Stephanie Marie G. Saren, Rain Stephanie I., Viray, Jessica Chelsea S.
260			_aQuezon City, Philippines, _bFEU-NRMF Dr. Nicanor Reyes Medical Foundation Institute of Medicine, _c2024
300			_a73pages _c28cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes Appendix
520			_aABSTRACT: Early detection of Alzheimer's Disease was challenging due to the lack of reliable biomarkers detect the disease before the onset of symptoms. The study aimed to systematically compare the individual and combined performance, in terms of sensitivity and specificity, of the biomarkers, namely amyloid beta protein (A3), total tau (t-tau), phosphorylated tau (p-tau) and neurofilament chain (Nfl) in the clinical setting as these are the commonly used hallmarks, except NFL which is new, for diagnosis of AD. The search for scholarly articles was guided by the PRISMA Framework. The risk of bias assessment complied with the Q. UADAS-2 Checklist and that can STATA was used for the forest plot. Of 142 studies initially identified from the databases, 44 studies made it through the quality evaluation. ELISA was the method of detection used by most studies. All individual and combined biomarkers had good to excellent discriminatory ability to diagnose patients with and without AD except for t-tau + NFL. Individually, p-tau is the most reliable biomarker with the highest value of 86 (95% Cl) and the lowest I2 with 63.8 which exhibits low heterogeneity. Among the combinations of biomarkers, the most promising is p-tau + beta amyloid, with an AUC of 92. However, moderate to high heterogeneity together with long ranges of specificity and sensitivity was present in the biomarker’s subgroup, possibly due to the lack of subgroup analysis and by different contexts such as the different use of samples, methodologies and modalities against the reference articles. The findings highlighted the potential of biomarker combinations to improve the accuracy of diagnosis and risk prediction for the disease but the issue of heterogeneity requires more attention. KEYWORDS: Alzheimer's Disease (AD), biomarkers, sensitivity\ specificity.
521			_abri'oot
700			_aBaetiong, Kai Irish D., _eauthor
700			_aDel Rosario, Hannah Sophia D.S., _eauthor
700			_aManingding, Jereez Xean J. _eauthor
700			_aManuel, Dainty Jewel C., _eauthor
700			_aMercado, Romulo III D., _eauthor
700			_aQuizana, Jezzel Mae G., _eauthor
700			_aSantiago, Stephanie Marie G. _eauthor
700			_aSaren, Rain Stephanie I _eauthor
700			_aViray, Jessica Chelsea S. _eauthor
856			_21 _30 _qpdf _uhttps://library.feu-nrmf.ph/cgi-bin/koha/opac-retrieve-file.pl?id=655ea3e1f88927577bd1587681269c30 _yClick here for FULL TEXT _1ALL
942			_2lcc _cTH
999			_c13154 _d13154