000			03594nam a22003617a 4500
001			T002865
003			PILC
005			20241029101320.0
008			241029b |||||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _drda
050			_aMT 2024 0020 c.1
100	1		_aBaloaloa,Eisenhower C _eauthor
245	0	1	_aA systematic review on utilizing stool specimens for rapid molecular diagnosis of pediatric tuberculosis _b[author]: Baloaloa,Eisenhower C., Billones,Faith Elijah M., Dela Cruz,Azrielle Minna L., Garcia,Justine Mhae R. Guyapa, Angel Erika S., Lariosa,Jahzeel Evi F., Madamba,Marikabelle Maxinne B., Molina,Charmaine Nikki G. Samillano,Ma. Nicole C., Valdez,Jan Vincent R., Villones,Laela Bianca B.
260			_aQuezon City, Philippines; _bFEU-NRMF Dr. Nicanor Reyes Medical Foundation Institute of Medicine, _c2024
300			_a62pages _c28cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes Appendix
520			_aABSTRACT: Pulmonary tuberculosis (TB), brought about by the Mycobacterium tuberculosis (MTB), is an airborne infection commonly affecting the lungs. Over one million children worldwide were diagnosed with tuberculosis each year, thus, considering it as one of the primary factors contributing to fatalities in the pediatric population. This study sought to provide relevant and consolidated data from other studies, focusing on the diagnostic efficacy of Xpert MTB/Rif Assay and Xpert MTB/Rif Ultra to influence tuberculosis diagnostic approaches and to potentially advocate for the use of stool samples as an alternative to invasive sputum sampling. The researchers used Researchgate, PubMed, and American Journal of Microbiology to search for eligible studies based on the eligibility criteria and to properly conclude if the studies made it to final screening, QUADAS-2 tool is utilized. This paper is statistically treated using Stata 17. 241 studies were retrieved from reliable databases, 53 were subjected to risk of bias assessment, finally only 9 studies were eligible for inclusion. GeneXpert MTB/Rif Assay pooled sensitivity was 62.0% (95% Cl: 42% - 78%), the overall specificity on the other hand was 100% (95% Cl: 99% - 100%). With GeneXpert MTB/Rif Ultra, its overall weighted sensitivity was 57% (95% Cl: 47% - 66%), ranging from 38% to 69%. Overall specificity of stool GeneXpert MTB/Rif Ultra was 98% (95% Cl: 92% - 100%), ranging from 90% to 100%. GeneXpert MTB/Rif Assay similarly tends to be more specific as compared to GeneXpert MTB/Rif Ultra. Specimen handling, disease burden on patients, amount of specimen provided by the patients, and specific processing methods can influence the increased sensitivity and specificity of both the GeneXpert MTB/Rif Assay and GeneXpert MTB/Rif Ultra. KEYWORDS: Pulmonary Tuberculosis, Xpert MTB/Rif Assay, Xpert MTB/Rif Ultra Assay
521			_abri'oot
700			_aBillones,Faith Elijah M., _eauthor
700			_aDela Cruz,Azrielle Minna L., _eauthor
700			_aGarcia,Justine Mhae R. _eauthor
700			_aGuyapa, Angel Erika S., _eauthor
700			_aLariosa,Jahzeel Evi F _eauthor
700			_aMadamba,Marikabelle Maxinne B., _eauthor
700			_aMolina,Charmaine Nikki G. _eauthor
700			_aSamillano,Ma. Nicole C., _eauthor
700			_aValdez,Jan Vincent R., _eVillones,Laela Bianca B.
856			_21 _30 _qpdf _uhttps://library.feu-nrmf.ph/cgi-bin/koha/opac-retrieve-file.pl?id=c9ec0cf1b22ad0ddddbd583ea14cfd6a _yClick here for FULL TEXT _1ALL
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