000 02411nam a22002657a 4500
999 _c7988
_d7988
001 M BIO 1999 0003
003 PILC
005 20240720152608.0
008 160505b1999 xxu||||| |||| 00| 0 eng d
040 _beng
_cFEU-NRMF MEDICAL LIBRARY
_erda
041 _aenglish
050 _aM BIO 1999 0003
245 _aA Comparative study on the stability of liposomes from chicken egg yolk's phospholipid to that of commercially prepared phospholipid treated with d-tocopherol /
_c1 Section A2; Michael Paul Tan.
260 _aManila:
_bDepartment of Biochemistry, FEU-NRMF,
_c1999.
300 _a37 pages:
_billustration, tables;
_c28 cm.
336 _2rdacontent
_atext
337 _2rdamedia
_aunmediated
338 _2rdacarrier
_avolume
504 _aIncludes appendices and bibliographical references.
520 _aAbstract: Liposomes are effective vehicles in carrying therapeutic drugs and agents. The effectiveness of this active agent delivery system is largerly dependent on the stability of the liposomes` bilipid membrane. The stability is strengthen by the anti-oxidizing property of Vitamin E (D-tocopherol). Vitamin E acts as a scavenger of free radicals protecting the unsaturated bonds of the fatty acids in the bilipid membrane from destabilization by agents like hydrogen peroxide. D-tocopherol was applied to the bilipid membrane of liposomes formed from commercially purified phospholipids and to liposomes formed from phospholipids extracted from native chicken egg yolk. Fatty acid peroxidation was induced, and the percentage protection rendered by D-tocopherol was determined. A value of 63.02% protection for unsaturated fatty acid bonds in liposomes formed from commercially purified phospholipids was calculate, and a value of 33.33% protection for unsaturated fatty acids bonds in liposomes formed from phospholipid extracted from native chicken egg yolk was calculated. A comparison of the percentage protection of the unsaturated bonds of egg liposomes in the negative control and in the experiment is statistically significant (Z=3.17).A comparison of the percentage protection of the unsaturated bonds of liposomes formed from commercially purified phospholipids in the negative control and in the experience is statistically not significant (Z=1.68).
521 _aTHDBN
700 _a1 Section A2
_eauthor
700 _aTan, Michael Paul, MD.
_eadviser
942 _2lcc
_cRU