000			03576nam a22003737a 4500
999			_c8021 _d8021
001			OB 2013 0006
003			PILC
005			20240720152610.0
008			160505b2013 xxu||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _erda
041			_aenglish
050			_aOB 2013 0006
245			_aEfficacy of dequalinium vaginal suppository in the treatment of bacterial vaginosis compared with standard metronidazole oral regimen : _ba randomized controlled trial / _cAngela Eulalia Maling-Rugay, Romerico F. Torres and Lylah D. Reyes.
260			_aFairview, Quezon City: _bDepartment of Obstetrics and Gynecology, FEU-NRMF _c2013.
300			_a45 pages: _billustrations, tables; _c(in folder).
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes appendices and bibliographical references.
520			_aAbstract: The standard treatment for bacterial vaginosis is metronidazole. Side effects are not well tolerated by some patients and some develop resistance. Hence the search for treatment with less side effects and less resistance. To determine the efficacy of vaginal dequalinium chloride compared to oralmetronidazole in the treatment of bacterial vaginosis among non pregnant women. Fourty non-pregnant women and non-lactating women, 18-50 years old diagnosed with bacterial vaginosis by presence of vaginal discharge and malodor, Nugent's score of 4 and above, and clue cells seen in Gram stain, were randomly allocated to treatment groups. Group A received dequalinium chloride 10mg/vaginal tablet for 6 days at HS while Group B received metronidazole tablet, 500mg/tablet, 1 tablet per orem BID for 7 days. Microbiologic, clinical and complete cure rate as well as adverse effects of treatment were then assessed. Data entry and encoding was done using Epi info version 6. Analysis was done using stata version 9. Univariate analysis such as mean, median, mode and range were used to describe the characteristics of the subjects. Frequency distribution was used to describe the proportion of patients with microbiologic, clinical and complete cure. This was also used in describing proportion of the participants' acceptability in this study. Chi square will be used for comparison of dequalinum chloride and metronidazole between treatment-arms. Ninety five percent (19/20) of those in the dequalinium arm had gram-negative coccobacilli count of less than 10/hpf as compared to 80% (16/20) among those in the contol (p < 0.03). Lacbacilli was only restored among 25% of those in the metronidazole the and in 75% of the control group (p= 0.002). Reduced amount of discharge was observed in all participants in both two groups. Malodor of the discharge disappeared in 95% (19/20) of the H202 and 85% (17/20) of the control group (p=0.30). Dequalinium is comparable with the standard treatment. It is at par with the standard treatment in alleviating symptoms of bacterial vaginosis and reducing estimated coccobacilli. It is more effacious in restoring the normal flora.
521			_aRESDOG
650			_abacterial vaginosis
650			_adequalinium chloride
650			_ametronidazole
650			_agardnella vaginalis
650			_aprovetella species
650			_amycoplasma hominis
650			_amobolincus
650			_afusobacterium
700			_aMaling-Rugay, Angela Eulalia, MD. _eprincipal investigator
700			_aTorres, Romerico F., MD. _eco-author
700			_aReyes, Lylah D., MD. _esupervising investigator
942			_2lcc _cRU