000			01757nam a22002657a 4500
999			_c8073 _d8073
001			ANES 2010 0004
003			PILC
005			20240720152613.0
008			160505b2010 xxu||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _erda
041			_aenglish
050			_aANES 2010 0004
245			_aMalignant hyperthermia : _ba case report / _cSara A. Bonoan.
260			_aFairview, Quezon City: _bDepartment of Anesthesiology, FEU-NRMF, _c2010.
300			_a18 pages: _btables; _c(in folder)
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes appendices and bibliographical references.
520			_aAbstract; Malignant htperthermia (MH) is a rare pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as isoflurane and depolarizing neuromuscular blocking agent, succinycholine. It is said to be to a defective calcium channel located in the sarcoplasmic reticulum membrane called the ryanodine receptor.\ Presented is a case of a 55 year old male who underwent direct laryngoscopy under general anesthesia in which the classic signs of MH were observed such as hyperthermia to a marked degree, tachycardia, tachypnea, increased end-tidal carbon-dioxide, acidosis, muscle rigidity and rhaabdomyolysis. These pathophysiologic changes of MH could lead to life-threatening complications like renal failure from rhabdomyolysis and disseminated intravascular coagulation (DIC) which were seen in our patient, hence the demise despite resuscitative measures and treatment.
521			_aRESDA
650			_amalignant hyperthermia
700			_aBonoan, Sara A., MD. _eauthor
942			_2lcc _cRU