000			01815nam a22002537a 4500
999			_c8276 _d8276
003			MED20150004
005			20240720152623.0
008			160505b2015 xxu||||| |||| 00| 0 eng d
040			_cFEU-NRMF MEDICAL LIBRARY
041			_aEnglish
050			_aMED20150004
100			_aRivera, Lorelie Ann C., MD. _eauthor
245			_a"Small but terrible" : _ba rare case of olfactory neuroblastoma successfully treated by chemotherapy / _cLorelie Ann C. Rivera.
260			_aFairview, Quezon City _bDepartment of Medicine, FEU-NRMF, _c2015
300			_bphotos (colored); _c(in folder)
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes bibliographical references.
520			_aABSTRACT: We report a rare case of olfactory neuroblastoma in a 23 year old female who presented with 3 month history of recurrent nasal congestion associated with intermittent headache, unilateral epistaxis and proptosis of left eye. Cranial MRI with contrast showed a large enhancing sinonasal and anterior skull base mass measuring 6.9x6.3x6.1 cm. Enlarged lymph nodes, right high jugular region and both lateral retropharyngeal spaces. Nasal endoscopy with biopsy revealed fibrocollagenous tissue composed of round cells arranged in sheets, cords and clusters some are separated by thin fibrous tissue. The cells have mild pleomorphism, granular chromatin pattern and scant cytoplasm. With areas of necrosis, congestion and hemorrhage. The findings are consistent with olfactory neuroblastoma. Immunohistochemical staining for Synaptophysin revealed positive, diffuse and strong cytoplasmic expression in neoplastic cells. Chromogranin revealed negative expression in neoplastic cells.
521			_aRESDM
887			_aRC RC 0009-15
942			_2lcc _cRE