000			02232nam a22002657a 4500
999			_c8658 _d8658
001			M BIO 2012 0004
003			PILC
005			20240720152651.0
008			160505b2012 xxu||||| |||| 00| 0 eng d
040			_beng _cFEU-NRMF MEDICAL LIBRARY _erda
041			_aenglish
050			_aM BIO 2012 0004
245			_aThe Effect of lycopene from lycopene capsule (lyc-O-mato) on isoniazid-induced seizure in imprinting controlled region (ICR) mice / _cSection E2; Dennis Ivan Bravo.
260			_aFairview, Quezon City: _bDepartment of Biochemistry, FEU-NRMF, _c2012.
300			_a70 pages: _billustrations tables, photos; _c28 cm.
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrirer _avolume
504			_aIncludes appendices and bibliographical references.
520			_aAbstract: Antioxidanta have been linked with anticonvulsnt properties. Lycopene is a well known compound that has antioxidant property and is popularly found in tomatoes. This study aims to determine effect of lycopene from lycopene capsule (Lyc-O-Mato) on the duration of isoniazid-induced seizures in ICR mice as an alternatve therapy to commercially available anti-seizure drug. Fourty-three (43) mice of either sex were grouped according to their respective treatments as follows: diazepan 10 mg/kg, lycopene concentrate of 20mg/kg and a negative control group. After which, they were subjected to isoniazid-induced seizure. Seizure activity was video recorded and graded using the Revised Racine`s Scale. P-values of <0.05 indicate significant differences. Statistical analyses used are One-Way ANOVA, with Duncan`s Multiple Range Test (DMRT), Kruskal - Wallis Analysis of Variance, with Student-Newman-Keuls (S-N-K) test for post hoc analysis and Fisher`s exact test. Results showed that the average duration of all the groups are the same. On the countrary, lycopene of any dosage or diazepam mostly manifested motionless staring compared to the control. Therefore, lycopene from lycopene capsule did not have a very significant effect on isoniazid-induce seizure activity of ICR mice.
521			_aTHDBN
700			_aSection E2 _eauthor
700			_aBravo, Dennis Ivan, MD. _eadviser
942			_2lcc _cRU