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999			_c8915 _d8915
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003			PILC
005			20240720152726.0
008			160505b xxu||||| |||| 00| 0 eng dND
040			_cFEU-NRMF MEDICAL LIBRARY
041			_aEnglish
050			_aTHE M-PHAR ND 0029
100			_aAngeles, Glenda
245			_aEFFECTS OF MONOTHERAPHY OF VALPROATE OR CARBAMAZEPINE COMPARED WITH COMBINATION OF BOTH DRUGS ON THE STRENGTH AND COORDINATION OF ALBINO RATS
264		0	_cND
336			_aText
337			_aUnmediated
338			_aVolume
502			_bPharmacology _gThesis
520			_aIt has been a well-known fact that anti-epileptic drugs are associated with numerous kinds of toxicity. Much toxicity associated with the use of these antiepileptic drugs has been attributed to its mechanism of its specific action. The study is designed to determine the degree of adverse effects caused by combining two antiepileptic drugs of different action and comparing it with the same drugs given as a monotherapy. It is hoped that this study will be able to demonstrate a comparative association of toxicity with multiple drug therapy of antiepileptic drugs. The experiment required the following drug dosages to elicit toxicity. In-group A, no drug was given because this is the control group B was given Valproate with a dosage of 120 mg/kg. Group C was given Carbamazepine at a dosage of 1 gm.kg. The last group, Group D was given the drug combination of Valproate and Carbamazepine which was given at different time to differences of half-lives of these two drugs. The first drug to be administered is Carbamazepine followed by Valproate after 4 hours. Endurance was measured by determining the length of time the rats stayed on the wheel.
700			_aAtanacio, Darwin
700			_aDario, Dionette Francis
700			_aDel Rosario, Shiella Marie
700			_aGo, Catherine
700			_aRamon, Jose Lenandro
700			_aTecson, Mary Anne
700			_aZuniga, Albert Robin;
942			_2lcc _cTH