000 02298nam a22003497a 4500
999 _c8976
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001 5489
003 PILC
005 20240720152732.0
008 160505b2001 xxu||||| |||| 00| 0 eng d
040 _cFEU-NRMF MEDICAL LIBRARY
041 _aEnglish
050 _aTHE M-PHAR 2001 0016
100 _aAncheta, Karen Lyn
245 _aA COMPARATIVE STUDY ON THE SEDATIVE ACTION OF LETTUCE (LACTUSA SATIVA) AND DIAZEPAM (VALIUM) ON MALE CATS
264 0 _c2001
300 _a28 NO. OF PAGES
336 _aText
337 _aUnmediated
338 _aVolume
502 _bPharmacology
_gThesis
520 _aSedation plays an important role on the field of medicine, among them is on surgery, research, experiment, treatment, or anaesthetics. Using the alkaloid extract of lettuce (Lactuca sativa), the research aims to establish the sedating effects produced by the extract on the experimental animals (cats) causing sedation upon application of the alkaloid extract. The alkaloid extract acts on the gamma-amino butyric acid (GABA) receptors. Thus, triggers the opening of the chloride channel, which leads to an increase in chloride conductance causing inhibition of the formation of action potential. The research study made use of ten make cats as experimental animals. They were designated into two groups, the first 5 cats treated with diazepan (valuium), and the next 5 cats treated with the alkaloid extract from lettuce. The research design used in the study was just a single dose trial. Initial condition of the experimental animals were observed and noted served as the baseline value. Data were evaluated and analyzed. Group A showed maximum effects of sedation, while group moderate effects of sedation. Despite of the noted change in the conditions of cats, the research needs further study and evaluation by producing a more concentrated and potent alkaloid extract from lettuce and a serial of test with increasing dosage of extract is highly recommended.
521 _afarmakoloji
700 _aBuco, Jennifer
700 _aCreus, Aimee
700 _aDe Jesus, Emmanuel
700 _aDolendo, Ann
700 _aJacinto, Mary Rose
700 _aMalveda, Agnes
700 _aRobledo, Abigail
700 _aTan, Elizabeth
942 _2lcc
_cTH