000			03727nam a22005177a 4500
999			_c9037 _d9037
001			5551
003			PILC
005			20240720152738.0
008			160505b2010 xxu||||| |||| 00| 0 eng d
040			_cFEU-NRMF MEDICAL LIBRARY
041			_aEnglish
050			_aTHE M-PHAR 2010 0003
100			_aAbarintos, Carla
245			_a"THE EFFECT OF GLIRICIDIA SEPIUM, KAKAWATI BARK EXTRACT ON WOUND CONTRACTION ON CAVIUS PORCELLIUS"
264		0	_c2010
300			_a39 NO. OF PAGES
336			_aText
337			_aUnmediated
338			_aVolume
502			_bPharmacology _gThesis
520			_aThe purpose of treating wounds locally (topical) or systematically (oral or parenteral) is to either shorten the time required for healing or to minimize the undesired consequences. However, apart from the associated side-effects that can affect individuals in different ways, there is an increasing health concern high regarding high cost of these drugs. The aim of this research was to compare the effect of the bark extract of G. espium (kakawati) on wound contraction with a standard. Wound excision of three (3) 9mm full thickness piece of the skin and a 10 mm distance in between each wound removed using scalpel, were done on the dorsal side of 10 guinea pigs. Each guinea pig was given Solcoseryl as positive control, negative control, and G. sepium extract once a day until all wounds were healed. Measurement of the wound size were traced everyday until healed and encoded using SPSS Statistical Analysis. The results were interpreted using two-way Anova and paired t-test. Analysis showed that there is a significant difference between positive control and the kakawati extract. This tells that the positive control is better in treating the wounds in terms of duration of healing as measured in wound length. Also, a significant difference has been found between the extract and negative control. The kakawati extract is better in treating the wounds in terms of duration of healing as measured in wound length. Therefore, treatment of wound using the extract of G. sepium (kakawati) offers a possibility of being used as an alternative organic medication to other costly chemical drugs used for treatment of wounds. Since the study is purely base on gross/visual observation of the guinea pig wounds treated with pure extract of G.sepium, it is recommended hereby that there must be a histological examination of the wounds in order to validate phases of healing process; depth of the wounds must be equally excised; to use agent in the wounds of higher forms of vertebral animals; and to validate the bactericidal efficacy of kakawati (G.sepium). It is also recommended to mix other concentrations with other drugs/agents that may have a synergistic or additive effects with kakawati and to identify the toxicity leveel and/or adverse effects of the extract.
700			_aAlcalde, Ma. Kathrina
700			_aAlicando, Ezekiel John
700			_aBohol, Marie Cris Guillerma
700			_aBuemio, Kristal Cielo
700			_aChua, Anna Lyn
700			_aDaquigan, Anna Katrina
700			_aDe leon, Rizza Elaine
700			_aEscabillas, Cyrus
700			_aGalang Jhakelinn Veericah
700			_aGenuino, Divine Grace
700			_aLarang, Chernobyll
700			_aLisondra, Maria Leandra
700			_aPerez, Catherine
700			_aRimando, Sheena
700			_aRosario, Jaja Mae
700			_aSan Gil, Katrina Paola
700			_aSantos, Sheena
700			_aSison, Jevi Ann
700			_aTuazon, Kelvin
700			_aTamesis, Steven
700			_aVicarez, Chelsea
700			_aSan Pedro, Rey Eleazar
700			_aZamora, Mark
942			_2lcc _cTH