The Malignant transformation of a dermoid cyst : a case report / Marie Rheapaz De Guzman.

By:

De Guzman, Marie Rheapaz, MD [author]

Language: English Publication details: Fairview, Quezon City Department of Obstetrics and Gynecology, FEU-NRMF, 2018Description: pholots (colored); (in folder)Content type:

rdacontent

Media type:

rdamedia

Carrier type:

rdacarrier

LOC classification:

OB20180002

Summary: ABSTRACT: The question weather patients with squamous cell carcinoma in a mature cystic teratoma should undergo conservative surgery or postoperative adjuvant treatment remains unresolved. Ovarian cancer is the second most common malignancy of the lower part of the female genital tract, occurring less frequently than cancers of the endometrium but more frequently than cancers of the cervix. Germ cell tumors are the second most frequent type of ovarian neoplasm and account for approximately 10-20% of all ovarian tumors. The most frequent germ cell tumor is the Mature Cystic Teratoma (Dermoid Cyst); overall, only 2% to 3% of germ cell tumors are malignant, and more than 80% of malignant transformations are squamous cell carcinomas arising from the ectoderm; the rest are carcinoid tumors or adnocarcinomas. There are currently no reliable procedures for the early detection of ovarian cancer. Available potential screening techniques have included pelvic examination, ultrasound examination, serum CA-125 determination and other tumor makers and combined modality approaches. A mass in the adnexa may be symptomatic or discovered incidentally on pelvic examination or imaging. There is no established definite treatment protocol available due to lack of research on this rare case, thus frozen Section of the affected ovary is imperative in dermoid cysts to ensure that it is benign. In both Gynecologic and General Surgical practice, frozen sections are utilized mainly to aid in the differentiation of benign from malignant disease. Determining the type of tumor and extent of surgery is very important in Gynecologic Oncology. In this report, we present a rare case of a mature cystic teratoma which found to be malignant on frozen section with Intraoperative Stage I-A, and therefore managed by cytoreductive surgery followed by chemotherapy.

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Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Research	Far Eastern University - Nicanor Reyes Medical Foundation Research	OB20180002 (Browse shelf(Opens below))	Available		R000602

Includes appendices and bibliographical references.

ABSTRACT: The question weather patients with squamous cell carcinoma in a mature cystic teratoma should undergo conservative surgery or postoperative adjuvant treatment remains unresolved. Ovarian cancer is the second most common malignancy of the lower part of the female genital tract, occurring less frequently than cancers of the endometrium but more frequently than cancers of the cervix. Germ cell tumors are the second most frequent type of ovarian neoplasm and account for approximately 10-20% of all ovarian tumors. The most frequent germ cell tumor is the Mature Cystic Teratoma (Dermoid Cyst); overall, only 2% to 3% of germ cell tumors are malignant, and more than 80% of malignant transformations are squamous cell carcinomas arising from the ectoderm; the rest are carcinoid tumors or adnocarcinomas. There are currently no reliable procedures for the early detection of ovarian cancer. Available potential screening techniques have included pelvic examination, ultrasound examination, serum CA-125 determination and other tumor makers and combined modality approaches. A mass in the adnexa may be symptomatic or discovered incidentally on pelvic examination or imaging. There is no established definite treatment protocol available due to lack of research on this rare case, thus frozen Section of the affected ovary is imperative in dermoid cysts to ensure that it is benign. In both Gynecologic and General Surgical practice, frozen sections are utilized mainly to aid in the differentiation of benign from malignant disease. Determining the type of tumor and extent of surgery is very important in Gynecologic Oncology. In this report, we present a rare case of a mature cystic teratoma which found to be malignant on frozen section with Intraoperative Stage I-A, and therefore managed by cytoreductive surgery followed by chemotherapy.

Research - Department of Obstetrics & Gynecology

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