The Use of QRISK3 VS framingham in the estimation of cardiovascular disease risk in patients with systematic lupus erythematosus : a retrospective cohort study / Kayla Pamela B. de la Cerna.

Contributor(s):

de la Cerna, Kayla Pamela B., MD [author]

Language: english Publication details: Fairview, Quezon City: Department of Internal Medicine, FEU-NRMF, 2022.Description: illustrations, tables; (in folder) with flash drive (soft copy)Content type:

text

Media type:

unmediated

Carrier type:

volume

LOC classification:

MED 2022 0004

Summary: Abstract: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients will systematic lupus enrythematosus (SLE). Studies have shown that SLE patient have a higher risk of developing cardiovascular diseases compared to the general population. Multiple prediction tools such as the Framingham Risk Score (FRS) has been used for primary prevention of CVD event. However, some studies reported that FRS has been shown to underestimate the risk in patients with SLE. In this retrospective study, we investigated and compared the use of QRISK and FRS in the estimation of cardiovascular events among patients with SLE. A total of 100 patients fulfilled the American College of Rheumatology criteria were included. At the end of the study, we report that patients with SLE had female preponderance. The traditional CVD risk factors, higher BMI and hypertension were commonly observed. The comparison of Framingham and QRISK3 in predicting risk of CVD events among SLE patients, results of the present study indicates that QRISK3 identified four times as many SLE patients with high CVD risk than Framingham. It is recommended that a multi-center study should be done to increase the sample size. Moreover, a prospective cross sectional study was also recommended to allow investigators to have a long term follow up with the CVD events.

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Holdings
Item type	Current library	Call number	Status	Notes	Date due	Barcode
Room Use	Far Eastern University - Nicanor Reyes Medical Foundation Research	MED 2022 0004 (Browse shelf(Opens below))	Available	with flash drive (soft copy)		R000696

Includes appendices and bibliographical references.

Abstract: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients will systematic lupus enrythematosus (SLE). Studies have shown that SLE patient have a higher risk of developing cardiovascular diseases compared to the general population. Multiple prediction tools such as the Framingham Risk Score (FRS) has been used for primary prevention of CVD event. However, some studies reported that FRS has been shown to underestimate the risk in patients with SLE. In this retrospective study, we investigated and compared the use of QRISK and FRS in the estimation of cardiovascular events among patients with SLE. A total of 100 patients fulfilled the American College of Rheumatology criteria were included. At the end of the study, we report that patients with SLE had female preponderance. The traditional CVD risk factors, higher BMI and hypertension were commonly observed. The comparison of Framingham and QRISK3 in predicting risk of CVD events among SLE patients, results of the present study indicates that QRISK3 identified four times as many SLE patients with high CVD risk than Framingham. It is recommended that a multi-center study should be done to increase the sample size. Moreover, a prospective cross sectional study was also recommended to allow investigators to have a long term follow up with the CVD events.

Research - Department of Medicine

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