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A descriptive study on the incidence of autoimmune diseases in patients who had sars-cov-2 infection./ [Principal Investigator]: Yu, Kimberly S.

Contributor(s): Language: English Publication details: Fairview, Quezon City: Department of Medicine, FEU-NRMF, 2023Description: (in folder) with flash drive (soft copy)Content type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
LOC classification:
  • MED 2023 0008
Online resources: Summary: ABSTRACT: Background: The emergence of the Severe Acute Respiratory Corona Virus 2 Syndrome (SARS-CoV-2) or COVID-19 in December 2019 has raised concerns about its potential to trigger autoimmune diseases. Previous researches have shown that viral infections can lead to autoimmune diseases through molecular mimicry; and SARS-CoV-2 has been found to disrupt normal antiviral immunity, potentially leading to autoimmune responses. Objectives: This study aims to investigate the prevalence of autoimmune diseases in patients following COVID-19 infection and vaccination, with a focus on the differences in prevalence between the two groups. This study also aims to explore the potential mechanisms by which SARS-CoV-2 may trigger autoimmune diseases. Methodology: A retrospective cohort study was conducted at FEU-NRMF Medical Center, involving adult patients diagnosed with autoimmune diseases post COVID-19 infection and vaccination from January 2022 to September 2023. Data from patient records were analyzed using univariate descriptive statistics to explore differences in prevalence and demographics between the two groups. Results: The study found that females were more prone to autoimmune diseases in both post COVID-19 infection and post COVID-19 vaccination. Psoriatic Arthritis and Systemic Lupus Erythematosus were prevalent autoimmune diseases in post COVID-19 infection, while Systemic Lupus Erythematosus and Rheumatoid Arthritis were prevalent in post COVID-19 vaccination. Additionally, the study revealed a higher prevalence of autoimmune diseases in post COVID-19 vaccination compared to post COVID-19 infection. The findings suggest a link between SARS-CoV-2 infection and vaccination with the development of autoimmune diseases, highlighting the need for further research and vigilance in monitoring autoimmune responses following COVID-19. Additionally, the study underscores the importance of considering gender-specific differences in autoimmune disease prevalence. Keywords: SARS-CoV-2, COVID-19, autoimmune diseases, vaccination, prevalence gender differences, molecular mimicry, immune response.
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Research Far Eastern University - Nicanor Reyes Medical Foundation MED 2023 0008 (Browse shelf(Opens below)) Available R000749

Includes bibliographical references.

ABSTRACT:
Background: The emergence of the Severe Acute Respiratory Corona Virus 2 Syndrome (SARS-CoV-2) or COVID-19 in December 2019 has raised concerns about its potential to trigger autoimmune diseases. Previous researches have shown that viral infections can lead to autoimmune diseases through molecular mimicry; and SARS-CoV-2 has been found to disrupt normal antiviral immunity, potentially leading to autoimmune responses.
Objectives: This study aims to investigate the prevalence of autoimmune diseases in patients following COVID-19 infection and vaccination, with a focus on the differences in prevalence between the two groups. This study also aims to explore the potential
mechanisms by which SARS-CoV-2 may trigger autoimmune diseases.
Methodology: A retrospective cohort study was conducted at FEU-NRMF Medical Center, involving adult patients diagnosed with autoimmune diseases post COVID-19 infection and vaccination from January 2022 to September 2023. Data from patient
records were analyzed using univariate descriptive statistics to explore differences in prevalence and demographics between the two groups.
Results: The study found that females were more prone to autoimmune diseases in both post COVID-19 infection and post COVID-19 vaccination. Psoriatic Arthritis and Systemic Lupus Erythematosus were prevalent autoimmune diseases in post COVID-19 infection, while Systemic Lupus Erythematosus and Rheumatoid Arthritis were prevalent in post COVID-19 vaccination. Additionally, the study revealed a higher prevalence of autoimmune diseases in post COVID-19 vaccination compared to post COVID-19
infection. The findings suggest a link between SARS-CoV-2 infection and vaccination with the development of autoimmune diseases, highlighting the need for further research and vigilance in monitoring autoimmune responses following COVID-19. Additionally, the study underscores the importance of considering gender-specific differences in autoimmune disease prevalence.
Keywords: SARS-CoV-2, COVID-19, autoimmune diseases, vaccination, prevalence
gender differences, molecular mimicry, immune response.

Department of Medicine Research - Department of Medicine

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