Platelet count/ spleen diameter ratio : validation of a noninvasive parameter to predict the presence of esophageal varices in patients with liver cirrhosis / Joy Sevilla.

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Includes appendices and bibliographical references.

ABSTRACT: Cirrhosis is an irreversible end stage liver disease associated with a spectrum of characteristic clinical manifestation and is the eleventh cause of death in the United States. The cardinal pathologic features reflect chronic injury of the hepatic parenchma and include extensive fibrosis in association with the formation of regenerative nodule. Patient frequently undergo screening endoscopy for the presence of esophageal varices. In the future, the social and medical burden will be increase due to a greater number of patient with chronic liver disease and their improved survival. In the study, our aim were to develop a noninvasive predictive tool which are the platelet count, splenomegaly and platelet cout/spleen ratio to identify esophageal varices in patient with liver cirrhosis. The demographic profile of patient with esophageal vaarices by esophagogastroscopy (EGD) and sensitivity and specificity of low platelet count and splenomegaly as well as the ratio in identifying esophageal varices in cirrhotic patients.

Research - Department of Medicine