Fishman's pulmonary diseases and disorders / editor-in-chief, Michael A. Grippi ; co-editors, Jack A. Elias, Jay A. Fishman, Robert M. Kotloff, Allan I. Pack, Robert M. Senior ; video editor, Mark D. Siegel

Preceded by Fishman's pulmonary diseases and disorders / editor-in-chief, Alfred P. Fishman ; co-editors, Jack A. Elias [and others]. 4th ed. c2008

Includes bibliographical references and index

Part 1: Perspectives. Milestones in the history of pulmonary medicine -- Part 2: Scientific Basis of Lung Function in Health and Disease. Genetic, cellular, and structural basis of normal lung function -- Functional design of the human lung for gas exchange -- The respiratory muscles -- Molecular regulation of lung development -- Pulmonary surfactant and disorders of surfactant homeostasis -- Mucociliary clearance -- The genetic basis of respiratory disorders -- Stem cells and respiratory disease: prospects for the future -- Personalized pulmonary medicine -- Physiological principles of normal lung function -- Pulmonary mechanics -- Control of ventilation -- Circadian rhythms and sleep biology -- Pulmonary circulation -- Ventilation, pulmonary blood flow, and ventilation-perfusion relationships -- Blood-gas transport -- Diffusion, chemical reactions, and diffusing capacity -- Acid-base balance -- The lungs in different physiological states -- Respiratory system response to exercise in health -- Aging of the respiratory system -- Lung immunology -- Innate and adaptive immunity in the lung -- Lymphocyte- and macrophage-mediated inflammation in the lung -- Mast cells and eosinophils -- Leukocyte accumulation in pulmonary disease -- Antibody-mediated lung defenses and humoral immunodeficiency -- Lung injury and repair -- T lymphocytes in the lung -- Chemokines, adipokines, and growth factors in the lung -- Redox signaling and oxidative stress in lung diseases -- Fibroblasts in lung homeostasis and disease

Part 3. Symptoms and Signs of Respiratory Disease. Clinical approach to the patient -- Approach to the patient with respiratory symptoms -- Modern approach to thoracic imaging diagnosis -- Thoracic ultrasonography -- Physiologic and metabolic study of pulmonary disorders using conventional imaging techniques and positron emission tomography -- Pulmonary function testing -- Principles and applications of cardiopulmonary exercise testing -- Diagnostic bronchoscopy, transthoracic needle biopsy, and related procedures -- Interventional bronchoscopy -- Diagnostic thoracic surgical procedures: Thoracoscopy, VATS, and thoracotomy -- Evaluation of respiratory impairment and disability -- Part 4. Obstructive Lung Diseases -- Pathology of chronic obstructive pulmonary disease: diagnostic features and differential diagnosis -- Chronic obstructive pulmonary disease: epidemiology, pathophysiology, pathogenesis, and [alpha]1-antitrypsin deficiency -- Cigarette smoking and smoking cessation -- Course and treatment of chronic obstructive pulmonary disease -- Rehabilitation in chronic pulmonary disease and other respiratory disorders -- The biology of asthma -- Asthma: epidemiology -- Asthma: clinical presentation and management -- Aspirin- and exercise-induced asthma -- Allergic bronchopulmonary aspergillosis (mycosis) and severe asthma with fungal sensitivity -- Upper airway obstruction in adults -- Cystic fibrosis -- Bronchiolitis -- Bullous disease of the lung -- Bronchiectasis --

Part 5. Interstitial and Inflammatory Lung Diseases -- Interstitial lung disease: a clinical overview and general approach -- Systemic sarcoidosis -- Idiopathic pulmonary fibrosis -- Idiopathic interstitial pneumonias other than idiopathic pulmonary fibrosis -- Hypersensitivity pneumonitis -- Radiation pneumonitis -- Pulmonary manifestations of the collagen vascular diseases -- Pulmonary Langerhans' cell histiocytosis --Pulmonary lymphangioleiomyomatosis -- Benign metastasizing leiomyoma -- Depositional diseases of the lungs -- Part 6. Drug-Induced Lung Diseases. Pulmonary toxicity related to chemotherapeutic agents -- Drug-induced pulmonary disease due to nonchemotherapeutic agents -- Part 7. Other Infiltrative and Airspace Disorders. The lungs in patients with inborn errors of metabolism -- Alveolar hemorrhage syndromes -- Aspiration-related pulmonary disorders -- Pulmonary alveolar proteinosis syndrome -- The eosinophilic pneumonias -- Part 8. Disorders of the Pulmonary Circulation. Pulmonary arterial hypertension -- Pulmonary thromboembolic disease -- Pulmonary vasculitis -- Pulmonary arteriovenous malformations --

Part 9. Disorders of the Pleural Space. Nonmalignant pleural effusions -- Malignant pleural effusions -- Pneumothorax -- Part 10. Diseases of the Mediastinum. Malignant mesothelioma and other primary pleural tumors -- Nonneoplastic disorders of the mediastinum -- Congenital cysts of the mediastinum: bronchopulmonary foregut anomalies -- Benign and malignant neoplasms of the mediastinum -- Part 11. Disorders of the Chest Wall, Diaphragm, and Spine. Nonmuscular diseases of the chest wall -- Effects of nonmuscular diseases on ventilation -- Management of neuromuscular respiratory muscle dysfunction -- Part 12. Occupational and Environmental Disorders. Asbestos-related lung disease -- Chronic beryllium disease and hard-metal lung diseases -- Coal workers' lung diseases and silicosis -- Occupational asthma, byssinosis, and industrial bronchitis -- Acute and chronic response to toxic inhalantions -- Indoor and outdoor pollution -- High-altitude physiology and clinical disorders -- Diving injuries and air embolism -- Thermal lung injury and acute smoke inhalation --

Part 13. Pulmonary Complications of Nonpulmonary Disorders. Noninfectious pulmonary complications of hematopoietic stem cell and solid organ transplantation -- Pulmonary complications of sickle cell disease -- Pulmonary disorders and pregnancy -- Pulmonary complications of intra-abdominal disease -- Part 14. Sleep and sleep disorders. Sleep apnea syndromes: central and obstructive -- Sleep-related hypoventilation syndromes -- Changes in the cardiorespiratory system during sleep -- Differential diagnosis and evaluation of sleepiness -- Part 15. Surgical Aspects of Pulmonary Medicine. Perioperative respiratory considerations in the surgical patient -- Acute respiratory failure in the surgical patient -- Perioperative care of the patient undergoing lung resection -- Thoracic trauma -- Lung transplantation -- Part 16. Neoplasms of the Lung. Genetic and molecular changes in lung cancer: prospects for a personalized pharmacological approach to treatment -- Epidemiology of lung cancer -- Approach to the patient with pulmonary nodules -- The pathology of bronchogenic carcinoma -- Clinical evaluation, diagnosis, and staging of lung cancer -- Treatment of non-small-cell lung cancer: surgery -- Treatment of non-small-cell lung cander: chemotherapy --

Treatment of non-small-cell lung cancer: radiation therapy -- Small cell lung cancer: diagnosis, treatment, and natural history -- Primary lung tumors other than bronchogenic carcinoma: benign and malignant -- Extrapulmonary syndromes associated with lung tumors -- Pulmonary metastases: the role of surgical resection -- Lymphoproliferative and hematologic diseases involving the lung and pleura -- Part 17. Infectious Diseases of the Lungs. Pulmonary clearance of infectious agents -- Approach to the patient with pulmonary infection -- Pulmonary infection in immunocompromised hosts -- Microbial virulence factors in pulmonary infections -- Principles of antibiotic use and the selection of empiric therapy for pneumonia -- Infections of the upper respiratory tract -- Aspiration, empyema, lung abscesses, and anaerobic infections -- Acute bronchitis and community-acquired pneumonia -- Healtcare-acquired pneumonia, including ventilator-associated pneumonia --

Viral infections of the lung and respiratory tract -- Tuberculosis -- Diseases due to nontuberculous mycobacteria -- Aspergillus, candida, and other opportunistic mold infections of the lung -- Cryptococcosis and the endemic mycoses -- Pneumocystis pneumonia -- Protozoan infections of the thorax -- Helminthic diseases of the lungs -- Zoonotic and other unusual bacterial pneumonias -- Part 18. Acute Respiratory Failure. Respiratory failure: an overview -- Acute respiratory distress syndrome: pathogenesis -- Acute lung injury and the acute respiratory distress syndrome: clinical features, management, and outcomes -- Sepsis, multiple organ dysfunction syndrome, and chronic critical illness -- Pump failure: the pathogenesis of hypercapnic respiratory failure in patients with lung and chest wall disease -- Oxygen therapy and toxicity -- Pulmonary pharmacotherapy -- Intubation and upper airway management -- Hemodynamic and respiratory monitoring in acute respiratory failure -- Principles of mechanical ventilation -- Nutrition in pulmonary disease -- Diagnosis and treatment of pain, agitation, and delirium in the intensive care unit -- Early mobilization of patients in the ICU -- Organization of intensive care units and long-term acute care hospitals -- Ethics and palliative care in critical care units

School of Respiratory Therapy