A Comparative study of the effectiveness of sodium picosulfate and lactulose as cleaning agents in bowel preparation for colonoscopy /
Morales, Marian M., MD.
A Comparative study of the effectiveness of sodium picosulfate and lactulose as cleaning agents in bowel preparation for colonoscopy / Marian M. Morales and Roy Caballero. - Fairview, Quezon City Department of Medicine, FEU-NRMF, 2016 - 15 pages: iilustrations, photos (some colored); (in folder)
Includes bibliographical references.
ABSTRACT: Colonoscopy is one of the procedures used as a means of visualization of the lower gastrointestinal tract and is indicated in many GI diseases and often used as screening tool for colon cancer. The ideal preparation for colonoscopy should reliably empty the colon of all fecal material in a rapid fashion with no gross or histologic alteration of the colonic mucosa. The preparation should be safe, convenient, tolerable, and inexpensive. This study aims to compare the effectiveness of Sodium Picosulfate and Lactulose among patients as cleansing agents for bowel preparation prior to colonoscopy. This is a retrospective cohort study involving patients who underwent colonoscopy procedure. Chart review of patients was done including the bowel preparation used, timing of colonoscopy, co-morbidities, and indication for colonoscopy. The outcome is the effectiveness of the bowel preparation used was evaluated using a 5 point validated scale with good interobserver reliability (Aronchick scale). Results showed that side effects such as headache was higher among those with lactulose (3.3% VS 0%, P=0.024 while vomiting was higher in Pico group (9.2% vs 3.9%, p=0.064 yet the difference was not significant. Moreover, using the Aronchick scale, the difference of ratings in both groups in the different scale levels were not statistically significant wherein both had higher ratings in scale 2 (39.5% vs 44.1%, p=0.416) followed by scale 1 (32.2% vs 30.9%, p=0.805). In conclusion, there is no significant difference in using Lactulose and Sodium Picosulfate as bowel preparation for colonoscopy based on the Aronchick scale. Moreover, the timing of colonoscopy in patients with Lactulose and Sodium Picosulfate were not statistically associated with their effectiveness based on Aronchick scale assessment. There was also no significant deference between the two preparation in terms of side effects, namely nausea, vomiting and headache.
Research - Department of Medicine
MED20160009
A Comparative study of the effectiveness of sodium picosulfate and lactulose as cleaning agents in bowel preparation for colonoscopy / Marian M. Morales and Roy Caballero. - Fairview, Quezon City Department of Medicine, FEU-NRMF, 2016 - 15 pages: iilustrations, photos (some colored); (in folder)
Includes bibliographical references.
ABSTRACT: Colonoscopy is one of the procedures used as a means of visualization of the lower gastrointestinal tract and is indicated in many GI diseases and often used as screening tool for colon cancer. The ideal preparation for colonoscopy should reliably empty the colon of all fecal material in a rapid fashion with no gross or histologic alteration of the colonic mucosa. The preparation should be safe, convenient, tolerable, and inexpensive. This study aims to compare the effectiveness of Sodium Picosulfate and Lactulose among patients as cleansing agents for bowel preparation prior to colonoscopy. This is a retrospective cohort study involving patients who underwent colonoscopy procedure. Chart review of patients was done including the bowel preparation used, timing of colonoscopy, co-morbidities, and indication for colonoscopy. The outcome is the effectiveness of the bowel preparation used was evaluated using a 5 point validated scale with good interobserver reliability (Aronchick scale). Results showed that side effects such as headache was higher among those with lactulose (3.3% VS 0%, P=0.024 while vomiting was higher in Pico group (9.2% vs 3.9%, p=0.064 yet the difference was not significant. Moreover, using the Aronchick scale, the difference of ratings in both groups in the different scale levels were not statistically significant wherein both had higher ratings in scale 2 (39.5% vs 44.1%, p=0.416) followed by scale 1 (32.2% vs 30.9%, p=0.805). In conclusion, there is no significant difference in using Lactulose and Sodium Picosulfate as bowel preparation for colonoscopy based on the Aronchick scale. Moreover, the timing of colonoscopy in patients with Lactulose and Sodium Picosulfate were not statistically associated with their effectiveness based on Aronchick scale assessment. There was also no significant deference between the two preparation in terms of side effects, namely nausea, vomiting and headache.
Research - Department of Medicine
MED20160009
