Chelation therapy in the treatment of metal intoxication /
Aaseth, Jan,
Chelation therapy in the treatment of metal intoxication / Jan Aaseth, Guido Criponi, Ole Andersen. - London, UK ; San Diego, CA, USA : Academic Press is an imprint of Elsevier, 2016. - xvi, 371 pages : illustrations ; 24 cm.
Includes bibliographical references and index.
Cover; Title Page; Copyright Page; Contents; Contributors; Preface; List of Abbreviations; Chapter 1 -- General Chemistry of Metal Toxicity and Basis for Metal Complexation; 1.1 -- General chemistry of metals; 1.2 -- Essential and nonessential elements; 1.3 -- Effects of toxic exposure of an essential or nonessential metal; 1.3.1 -- Basic Concepts in Chemical Toxicity Testing; 1.3.2 -- Exposure Patterns and Mechanisms of Metal Toxicity; 1.3.3 -- Gastrointestinal Effects of Metal Exposure; 1.3.4 -- Respiratory Effects of Metal Exposure; 1.3.5 -- Hepatic and Renal Effects. 1.3.6 -- Effects on the Nervous System1.3.7 -- Hematological Effects; 1.3.8 -- Cardiovascular Effects; 1.3.9 -- Metal Allergies; 1.3.10 -- Carcinogenic Effects; 1.4 -- Basis for metal complex formation with endogenous and exogenous ligands; 1.5 -- Endogenous complexing and detoxification compounds; 1.5.1 -- Albumin; 1.5.2 -- Transferrin and Ferritin; 1.5.3 -- Glutathione; 1.5.4 -- Metallothionein; 1.5.5 -- Selenoproteins; 1.6 -- Conclusions; References; Chapter 2 -- Chelating Agents as Therapeutic Compounds-Basic Principles; 2.1 -- Chemical and biological principles for in vivo chelation; 2.1.1 -- Stability. 2.1.2 -- Selectivity2.1.3 -- Kinetic Aspects of Chelation; 2.1.4 -- Absorption and Bioavailability of Chelating Agents; 2.2 -- Chelating agents: chemistry, kinetics, and toxicology; 2.2.1 -- BAL, DMPS, DMSA; 2.2.2 -- D-penicillamine; 2.2.3 -- Triethylenetetramine; 2.2.4 -- Deferoxamine, Deferiprone, and Deferasirox; 2.2.5 -- EDTA and DTPA; 2.2.6 -- Prussian Blue; References; Chapter 3 -- Diagnosis and Evaluation of Metal Poisonings and Chelation Therapy; 3.1 -- Introduction; 3.2 -- History of symptoms and exposure; 3.3 -- Clinical findings; 3.4 -- Genetic disorders with systemic metal accumulation. 3.5 -- Toxicological analyses3.6 -- Biochemical measurements; 3.7 -- Physiological, radiological, and ultrasonographic investigations; References; Chapter 4 -- Chelation Treatment During Acute and Chronic Metal Overexposures-Experimental and Clinical Studies; 4.1 -- Introduction; 4.2 -- Aluminum; 4.2.1 -- Selected Representative Animal Studies; 4.2.2 -- Selected Representative Clinical Studies; 4.2.3 -- Conclusions; 4.3 -- Antimony; 4.3.1 -- Animal Experiments; 4.3.2 -- Clinical Cases; 4.3.3 -- Conclusion; 4.4 -- Arsenic; 4.4.1 -- Selected Animal Experiments; 4.4.2 -- Clinical Studies. 4.4.3 -- Discussion and Conclusion4.5 -- Beryllium; 4.5.1 -- Experimental Chelation Studies; 4.5.2 -- Clinical Experience; 4.5.3 -- Conclusion; 4.6 -- Bismuth; 4.6.1 -- Animal Chelation Studies; 4.6.2 -- Clinical Chelation Studies; 4.6.3 -- Conclusion; 4.7 -- Cadmium; 4.7.1 -- Animal Chelation Experiments; 4.7.2 -- Clinical Chelation Studies; 4.7.3 -- Conclusion; 4.8 -- Chromium; 4.8.1 -- Animal Experimental Studies; 4.8.2 -- Clinical Cases; 4.8.3 -- Conclusion; 4.9 -- Cobalt; 4.9.1 -- Chelation, Animal Experiments; 4.9.2 -- Chelation, Clinical Studies; 4.9.3 -- Conclusion; 4.10 -- Copper. 4.10.1 -- Animal Chelation Studies.
Department of Pathology & Laboratory Diagnosis
9780128030721 0128030720
2016937843
Chelation therapy.--Toxicology
RA 1231.M52 .Aa77 2016
615.9/253
Chelation therapy in the treatment of metal intoxication / Jan Aaseth, Guido Criponi, Ole Andersen. - London, UK ; San Diego, CA, USA : Academic Press is an imprint of Elsevier, 2016. - xvi, 371 pages : illustrations ; 24 cm.
Includes bibliographical references and index.
Cover; Title Page; Copyright Page; Contents; Contributors; Preface; List of Abbreviations; Chapter 1 -- General Chemistry of Metal Toxicity and Basis for Metal Complexation; 1.1 -- General chemistry of metals; 1.2 -- Essential and nonessential elements; 1.3 -- Effects of toxic exposure of an essential or nonessential metal; 1.3.1 -- Basic Concepts in Chemical Toxicity Testing; 1.3.2 -- Exposure Patterns and Mechanisms of Metal Toxicity; 1.3.3 -- Gastrointestinal Effects of Metal Exposure; 1.3.4 -- Respiratory Effects of Metal Exposure; 1.3.5 -- Hepatic and Renal Effects. 1.3.6 -- Effects on the Nervous System1.3.7 -- Hematological Effects; 1.3.8 -- Cardiovascular Effects; 1.3.9 -- Metal Allergies; 1.3.10 -- Carcinogenic Effects; 1.4 -- Basis for metal complex formation with endogenous and exogenous ligands; 1.5 -- Endogenous complexing and detoxification compounds; 1.5.1 -- Albumin; 1.5.2 -- Transferrin and Ferritin; 1.5.3 -- Glutathione; 1.5.4 -- Metallothionein; 1.5.5 -- Selenoproteins; 1.6 -- Conclusions; References; Chapter 2 -- Chelating Agents as Therapeutic Compounds-Basic Principles; 2.1 -- Chemical and biological principles for in vivo chelation; 2.1.1 -- Stability. 2.1.2 -- Selectivity2.1.3 -- Kinetic Aspects of Chelation; 2.1.4 -- Absorption and Bioavailability of Chelating Agents; 2.2 -- Chelating agents: chemistry, kinetics, and toxicology; 2.2.1 -- BAL, DMPS, DMSA; 2.2.2 -- D-penicillamine; 2.2.3 -- Triethylenetetramine; 2.2.4 -- Deferoxamine, Deferiprone, and Deferasirox; 2.2.5 -- EDTA and DTPA; 2.2.6 -- Prussian Blue; References; Chapter 3 -- Diagnosis and Evaluation of Metal Poisonings and Chelation Therapy; 3.1 -- Introduction; 3.2 -- History of symptoms and exposure; 3.3 -- Clinical findings; 3.4 -- Genetic disorders with systemic metal accumulation. 3.5 -- Toxicological analyses3.6 -- Biochemical measurements; 3.7 -- Physiological, radiological, and ultrasonographic investigations; References; Chapter 4 -- Chelation Treatment During Acute and Chronic Metal Overexposures-Experimental and Clinical Studies; 4.1 -- Introduction; 4.2 -- Aluminum; 4.2.1 -- Selected Representative Animal Studies; 4.2.2 -- Selected Representative Clinical Studies; 4.2.3 -- Conclusions; 4.3 -- Antimony; 4.3.1 -- Animal Experiments; 4.3.2 -- Clinical Cases; 4.3.3 -- Conclusion; 4.4 -- Arsenic; 4.4.1 -- Selected Animal Experiments; 4.4.2 -- Clinical Studies. 4.4.3 -- Discussion and Conclusion4.5 -- Beryllium; 4.5.1 -- Experimental Chelation Studies; 4.5.2 -- Clinical Experience; 4.5.3 -- Conclusion; 4.6 -- Bismuth; 4.6.1 -- Animal Chelation Studies; 4.6.2 -- Clinical Chelation Studies; 4.6.3 -- Conclusion; 4.7 -- Cadmium; 4.7.1 -- Animal Chelation Experiments; 4.7.2 -- Clinical Chelation Studies; 4.7.3 -- Conclusion; 4.8 -- Chromium; 4.8.1 -- Animal Experimental Studies; 4.8.2 -- Clinical Cases; 4.8.3 -- Conclusion; 4.9 -- Cobalt; 4.9.1 -- Chelation, Animal Experiments; 4.9.2 -- Chelation, Clinical Studies; 4.9.3 -- Conclusion; 4.10 -- Copper. 4.10.1 -- Animal Chelation Studies.
Department of Pathology & Laboratory Diagnosis
9780128030721 0128030720
2016937843
Chelation therapy.--Toxicology
RA 1231.M52 .Aa77 2016
615.9/253
