Synchronous endometrioid endometrial and serous ovarian carcinoma : a gynecologic double jeopardy /
Synchronous endometrioid endometrial and serous ovarian carcinoma : a gynecologic double jeopardy /
Ana Victoria C. Crimen.
- Fairview, Quezon City: Department of Obstetrics and Gynecology, FEU-NRMF, 2020.
- 34 pages: photos; (in folder) with flash drive (soft copy).
Includes appendices and bibliographical references.
Abstract: Synchronous malignant tumors are two primary tumors diagnosed at the same time during surgery. A post-menopausal, nulligravid, presented with vaginal bleeding. Ultrasound revealed an endometrial and right ovarian mass, both with non-benign features. Cancer Antigen 125 and Human Epidydimis Protein 4 were elevated. She underwent Extrafascial Hysterectomy with Bilateral Salpingo-Oophorectomy with frozen section of Endometrium and Right Ovary, Bilateral Lymph Node Dissection. Histopathology report was Endometrioid Endometrial Carcinoma and High-Grade Serous Ovarian Carcinoma. The endometrial, ovarian, pelvic lymph nodes and the recto-sigmoid mass tissues positive for tumor cells were subjected to immunohistochemistry staining with Vimentin and Wilm's Tumor 1 (WT1), to establish which is the primary tumor and which tumor metastasized. The endometrial and ovarian tissues tested positive for Vimentin and WT1, respectively, suggesting both are primary independent tumors. The pelvic lymph nodes and recto-sigmoid lymph nodes tested positive for Vimentin and negative for WT1, suggesting endometrial tumor metastasis. The final diagnosis is Synchronous Endometrioid Endometrial Carcinoma Stage IIIC1 and High-Grade Serous Ovarian Carcinoma Stage IA, right ovary.
Research - Department of Obstetrics & Gynecology
Serous Ovarian Carcinoma
Endometrioid Endometrial Carcinoma
Nulligravid
Wilm's Tumor 1
Vimentin
Synchronous Malignant Tumors
OB 2020 0004
Includes appendices and bibliographical references.
Abstract: Synchronous malignant tumors are two primary tumors diagnosed at the same time during surgery. A post-menopausal, nulligravid, presented with vaginal bleeding. Ultrasound revealed an endometrial and right ovarian mass, both with non-benign features. Cancer Antigen 125 and Human Epidydimis Protein 4 were elevated. She underwent Extrafascial Hysterectomy with Bilateral Salpingo-Oophorectomy with frozen section of Endometrium and Right Ovary, Bilateral Lymph Node Dissection. Histopathology report was Endometrioid Endometrial Carcinoma and High-Grade Serous Ovarian Carcinoma. The endometrial, ovarian, pelvic lymph nodes and the recto-sigmoid mass tissues positive for tumor cells were subjected to immunohistochemistry staining with Vimentin and Wilm's Tumor 1 (WT1), to establish which is the primary tumor and which tumor metastasized. The endometrial and ovarian tissues tested positive for Vimentin and WT1, respectively, suggesting both are primary independent tumors. The pelvic lymph nodes and recto-sigmoid lymph nodes tested positive for Vimentin and negative for WT1, suggesting endometrial tumor metastasis. The final diagnosis is Synchronous Endometrioid Endometrial Carcinoma Stage IIIC1 and High-Grade Serous Ovarian Carcinoma Stage IA, right ovary.
Research - Department of Obstetrics & Gynecology
Serous Ovarian Carcinoma
Endometrioid Endometrial Carcinoma
Nulligravid
Wilm's Tumor 1
Vimentin
Synchronous Malignant Tumors
OB 2020 0004
