A Case report on cryptococcosis in an apparently immunocompetent individual /
A Case report on cryptococcosis in an apparently immunocompetent individual /
Djacob Rawland F. Domingo.
- Fairview, Quezon City: Department of Radiology, FEU-NRMF, 2020.
- tables, photos; (in floder).
Includes appendices and bibliographical references.
Abstract: Cryptococcosis is a disease that is known to affect immunocompromised individuals. It is rare among people who have normal immune capabilities. There are two species common among humans - Cryptococcus neoformans, which can be found in bird excreta or dropping and Cryptococcus gatti, which is usually seen in the tropic regions. It is the most common cause of fungal infection in the HIV/AIDS (Human immunodeficiency virus/ Acquired immunodeficiency syndrome) population. However, it can also affect other immunocompromised subjects, and in very rare instances, those with healthyimmune system. The portal of entry for this organism is through the lungs and it can disseminate in the central nervous system, mucocutaneous tissues, and bones. With such, Meningitis is considered the most serious complication of this infection. Pulmonary cryptococcosis has several patterns that can be seen in chest radiographs: single or multiple nodules or masses, single or multiple patch airspace opacities and multiple small nodules. Other findings such as cavitation, lymphadenopathy, and pleural effusion are usually seen in patients with AIDS rather than in normal hosts. As the most frequently reported CNS infection in HIV/AIDS population, its usual manifestation is Meningitis, although granulomas or cryptococcomas can be seen in brain imaging. Computed tomography (CT) scans in patient with crytococcosis are commonly normal but may demonstrate mild meningeal enhancement and/or hydrocephalus. Moreover, due to improved sensitivity of MR, parenchymal lesions and meningeal disease are now seen more frequently. Contrast enhanced T1 weighted imaging may show leptomeningeal nodules that are in areas near the basal cisterns and within sulci. A.S. is a 58 year old male, wood designer in Saudi Arabia, who recently had inability to work and was admitted for about 2 months due to recurring symptoms of severe headache, dizziness, confusion and syncope. Patient was diagnosed with cryptococcal meningitis. He decided to go back to our country upon being discharged to continue treatment and to have second opinion.
Research - Department of Radiology
RAD 2020 0002
Includes appendices and bibliographical references.
Abstract: Cryptococcosis is a disease that is known to affect immunocompromised individuals. It is rare among people who have normal immune capabilities. There are two species common among humans - Cryptococcus neoformans, which can be found in bird excreta or dropping and Cryptococcus gatti, which is usually seen in the tropic regions. It is the most common cause of fungal infection in the HIV/AIDS (Human immunodeficiency virus/ Acquired immunodeficiency syndrome) population. However, it can also affect other immunocompromised subjects, and in very rare instances, those with healthyimmune system. The portal of entry for this organism is through the lungs and it can disseminate in the central nervous system, mucocutaneous tissues, and bones. With such, Meningitis is considered the most serious complication of this infection. Pulmonary cryptococcosis has several patterns that can be seen in chest radiographs: single or multiple nodules or masses, single or multiple patch airspace opacities and multiple small nodules. Other findings such as cavitation, lymphadenopathy, and pleural effusion are usually seen in patients with AIDS rather than in normal hosts. As the most frequently reported CNS infection in HIV/AIDS population, its usual manifestation is Meningitis, although granulomas or cryptococcomas can be seen in brain imaging. Computed tomography (CT) scans in patient with crytococcosis are commonly normal but may demonstrate mild meningeal enhancement and/or hydrocephalus. Moreover, due to improved sensitivity of MR, parenchymal lesions and meningeal disease are now seen more frequently. Contrast enhanced T1 weighted imaging may show leptomeningeal nodules that are in areas near the basal cisterns and within sulci. A.S. is a 58 year old male, wood designer in Saudi Arabia, who recently had inability to work and was admitted for about 2 months due to recurring symptoms of severe headache, dizziness, confusion and syncope. Patient was diagnosed with cryptococcal meningitis. He decided to go back to our country upon being discharged to continue treatment and to have second opinion.
Research - Department of Radiology
RAD 2020 0002
