Anaplastic carcinoma of the thyroid : a case report /
Anaplastic carcinoma of the thyroid : a case report /
Francis S. Amponin.
- Fairview, Quezon City: Department of Clinical Laboratory, FEU-NRMF, 2012.
- 16 pages: photos; (in folder)
Includes bibliographical references.
Abstract: Anaplastic thyroid carcinoma (ATC) is one of the most lethal thyroid malignancies. Anaplastic carcinoma are rare undifferentiated tumors of the thyroid follicular epithelium, accounting for less than 2% of thyroid tumros. They are aggressive tumors with a very high mortality rates. The typical patient has a long standing neck mass, which rapidly enlarges and may be painful. Associated symptoms such as dysphonia, and dyspnea are common. Over a third of the patients with ATC have a long-standing goiter. Presented here is a c asae of a 58 year old female who is referred to this institution with a chief complaint of palpable, non-tender, non-movable mass on the anterior neck are measuring 18 x 12 x10 cm. Associated symptoms such as dysphagia and dyspnea are noted. The patient underwent tracheostomy with tumor debulking followed by 3 cycles of radiotherapy. Histopathologic examination of the mass showed a poorly differentiated carcinoma (anaplastic). Immunohistochemical stains such as cytokeratin, vimentin and leukocyte common antigen were done to improve diagnostic accuracy. Anaplastic thyroid carcinomas are difficult to diagnose because not all cases will show differentiation morphologically. Histologic patterns of ATC include spindle, giant and squamoid cell types. The differential diagnosis of undifferentiated or anaplastic thyroid carcinoma include sarcoma, solid variants of palillary carcinoma, poorly differentiated (insular) carcinoma, medullary carcinoma, malignant lymphoma and metastatic tumor. Immunohistochemical staining may be helpful to arrive on the right diagnosis.
Research - Department of Clinical Laboratory
PATH 2012 0001
Includes bibliographical references.
Abstract: Anaplastic thyroid carcinoma (ATC) is one of the most lethal thyroid malignancies. Anaplastic carcinoma are rare undifferentiated tumors of the thyroid follicular epithelium, accounting for less than 2% of thyroid tumros. They are aggressive tumors with a very high mortality rates. The typical patient has a long standing neck mass, which rapidly enlarges and may be painful. Associated symptoms such as dysphonia, and dyspnea are common. Over a third of the patients with ATC have a long-standing goiter. Presented here is a c asae of a 58 year old female who is referred to this institution with a chief complaint of palpable, non-tender, non-movable mass on the anterior neck are measuring 18 x 12 x10 cm. Associated symptoms such as dysphagia and dyspnea are noted. The patient underwent tracheostomy with tumor debulking followed by 3 cycles of radiotherapy. Histopathologic examination of the mass showed a poorly differentiated carcinoma (anaplastic). Immunohistochemical stains such as cytokeratin, vimentin and leukocyte common antigen were done to improve diagnostic accuracy. Anaplastic thyroid carcinomas are difficult to diagnose because not all cases will show differentiation morphologically. Histologic patterns of ATC include spindle, giant and squamoid cell types. The differential diagnosis of undifferentiated or anaplastic thyroid carcinoma include sarcoma, solid variants of palillary carcinoma, poorly differentiated (insular) carcinoma, medullary carcinoma, malignant lymphoma and metastatic tumor. Immunohistochemical staining may be helpful to arrive on the right diagnosis.
Research - Department of Clinical Laboratory
PATH 2012 0001
