Malignant hyperthermia : a case report /
Malignant hyperthermia : a case report /
Sara A. Bonoan.
- Fairview, Quezon City: Department of Anesthesiology, FEU-NRMF, 2010.
- 18 pages: tables; (in folder)
Includes appendices and bibliographical references.
Abstract; Malignant htperthermia (MH) is a rare pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as isoflurane and depolarizing neuromuscular blocking agent, succinycholine. It is said to be to a defective calcium channel located in the sarcoplasmic reticulum membrane called the ryanodine receptor.\ Presented is a case of a 55 year old male who underwent direct laryngoscopy under general anesthesia in which the classic signs of MH were observed such as hyperthermia to a marked degree, tachycardia, tachypnea, increased end-tidal carbon-dioxide, acidosis, muscle rigidity and rhaabdomyolysis. These pathophysiologic changes of MH could lead to life-threatening complications like renal failure from rhabdomyolysis and disseminated intravascular coagulation (DIC) which were seen in our patient, hence the demise despite resuscitative measures and treatment.
Research - Department of Anesthesiology
malignant hyperthermia
ANES 2010 0004
Includes appendices and bibliographical references.
Abstract; Malignant htperthermia (MH) is a rare pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as isoflurane and depolarizing neuromuscular blocking agent, succinycholine. It is said to be to a defective calcium channel located in the sarcoplasmic reticulum membrane called the ryanodine receptor.\ Presented is a case of a 55 year old male who underwent direct laryngoscopy under general anesthesia in which the classic signs of MH were observed such as hyperthermia to a marked degree, tachycardia, tachypnea, increased end-tidal carbon-dioxide, acidosis, muscle rigidity and rhaabdomyolysis. These pathophysiologic changes of MH could lead to life-threatening complications like renal failure from rhabdomyolysis and disseminated intravascular coagulation (DIC) which were seen in our patient, hence the demise despite resuscitative measures and treatment.
Research - Department of Anesthesiology
malignant hyperthermia
ANES 2010 0004
