Efficacy of intravenous paracetamol as preemptive analgesia in patients who underwent laparoscopic cholecystectomy /
Efficacy of intravenous paracetamol as preemptive analgesia in patients who underwent laparoscopic cholecystectomy /
Charlene Rose P. Syjuco.
- Fairview, Quezon City: Department of Anesthesiology, FEU-NRMF, 2015.
- 33 pages: illustrations, tables; (in folder)
Includes appendices and bibliographical references.
Abstract: Pain is the most common complaint of patients who underwent laparoscopic cholecystectomy requiring 80% of patients to receive opioid rescue dose. The objective of this study was to determine the efficacy of preemptive IV paracetamol in patients undergoing laparoscopic cholecystectomy. Sixty ASA (American Society of Anesthesiologist) 1 and 2 patients (> 18 years old) were included in this randomized, double-blind, controlled study, Group 1 receive IV paracetamol (1g) and group 2 received placebo, both one hour prior to procedure. Total number of top up of Fentanyl (25ug) intraoperatively and total number of rescue medication of Nalbuphine (5mg) postoperatively were the parameters assessed and compared in this study. Intensity of pain was assessed using the Visual analog scale(V A S) at different postoperative times ( 1h, 6h, 12h, 18h and 24h). The IV paracetamol group showed lower consumption of opioid intraoperatively (p<0.05) and postoperatively (p<0.05) than the placebo group. The IV Paracetamol group also showed lower pain intensity (p<0.05) than the placebo group at different time interval ( 1h, 6h and 12h). Preemptive IV paracetamol is an effective preemptive analgesic in patients who underwent laparoscopic cholecystectomy.
Research - Department of Anesthesiology
ANES 2015 0002
Includes appendices and bibliographical references.
Abstract: Pain is the most common complaint of patients who underwent laparoscopic cholecystectomy requiring 80% of patients to receive opioid rescue dose. The objective of this study was to determine the efficacy of preemptive IV paracetamol in patients undergoing laparoscopic cholecystectomy. Sixty ASA (American Society of Anesthesiologist) 1 and 2 patients (> 18 years old) were included in this randomized, double-blind, controlled study, Group 1 receive IV paracetamol (1g) and group 2 received placebo, both one hour prior to procedure. Total number of top up of Fentanyl (25ug) intraoperatively and total number of rescue medication of Nalbuphine (5mg) postoperatively were the parameters assessed and compared in this study. Intensity of pain was assessed using the Visual analog scale(V A S) at different postoperative times ( 1h, 6h, 12h, 18h and 24h). The IV paracetamol group showed lower consumption of opioid intraoperatively (p<0.05) and postoperatively (p<0.05) than the placebo group. The IV Paracetamol group also showed lower pain intensity (p<0.05) than the placebo group at different time interval ( 1h, 6h and 12h). Preemptive IV paracetamol is an effective preemptive analgesic in patients who underwent laparoscopic cholecystectomy.
Research - Department of Anesthesiology
ANES 2015 0002
