A Comparative study on the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of isoniazid (INH) by international, multinational, and local drug companies /
A Comparative study on the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of isoniazid (INH) by international, multinational, and local drug companies /
Jhoanna O. Delos Reyes, Aileen Rodora M. Abueg, Eric Emil M. Acosta, Aldrin A. Aldaba, Rhea Maureen S. Angeles, Zarina R. Balagtas, Ma. Rema C. Bello, James Dennis M. Bobis, Jerome Bolivar, Noriel L. Buenavente, Jeanette A. Catapang, Cherry Veil G. Cabisudo, Raymond Felix M. Collao, Jaybemi Comia, Cherry Y. Cortez, Marigil J. Dofiles, Allan A. Evangelista, Arnaldo L. Evangelista, Maryliza P. Evangelista, Flordeliza S.A. Fernando, Irene L. Gardiner and Tzy-Guei Hu.
- Fairview, Quezon City: Department of Community and Family Medicine, FEU-NRMF.
- illusrations, tables, photos; 28 cm.
Includes appendices and bibliographical references.
Abstract: The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Isoniazid manufactured by different Drug Companies were determined and investigated Six INH tablets were randomly chosen from the 4 selected Drug companies and were subjected to anti-microbial effectiveness testing in vitro using Broth Dilution Method. Results were analyzed using ANOVA and their cost-effectiveness were ascertained by comparing their unit price in relation to their bacteriostatic and bactericidal activity. It was found out that there was a significant difference in the antimicrobial effectiveness of the INH tablets from the selected Drug Companies. It was apparent that INH from Drug Company A, a multi-national drug companyy, exhibited the lowest concentration to inhibit tubercle bacilli growth as well as the lowest concentration to effectiively kill the tubercle colonies in the subcultures from non-turbid tubes. These INH tablets cost much more compared to the locally produced Isoniazid. However, the fact that its anti-microbial effectiveness is superior in comparison to the other INH tablets from the other Drug Companies it can be implied that it has the greatest advantage.
Thesis - Department of Community & Family Medicine
M CFM ND 0002
Includes appendices and bibliographical references.
Abstract: The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Isoniazid manufactured by different Drug Companies were determined and investigated Six INH tablets were randomly chosen from the 4 selected Drug companies and were subjected to anti-microbial effectiveness testing in vitro using Broth Dilution Method. Results were analyzed using ANOVA and their cost-effectiveness were ascertained by comparing their unit price in relation to their bacteriostatic and bactericidal activity. It was found out that there was a significant difference in the antimicrobial effectiveness of the INH tablets from the selected Drug Companies. It was apparent that INH from Drug Company A, a multi-national drug companyy, exhibited the lowest concentration to inhibit tubercle bacilli growth as well as the lowest concentration to effectiively kill the tubercle colonies in the subcultures from non-turbid tubes. These INH tablets cost much more compared to the locally produced Isoniazid. However, the fact that its anti-microbial effectiveness is superior in comparison to the other INH tablets from the other Drug Companies it can be implied that it has the greatest advantage.
Thesis - Department of Community & Family Medicine
M CFM ND 0002
