A COMPARATIVE STUDY OF THE EFFECTS OF GARLIC AND FISH OILS ON TOTAL CHOLESTEROL, TRIGLYCERIDE, LDL & HDL LEVELS ON MALE GUINEA PIGS (CAVIA PORCELLUS)
Alava, Dianne L.
A COMPARATIVE STUDY OF THE EFFECTS OF GARLIC AND FISH OILS ON TOTAL CHOLESTEROL, TRIGLYCERIDE, LDL & HDL LEVELS ON MALE GUINEA PIGS (CAVIA PORCELLUS)
The research aims to compare the effects of garlic and fish oil on the cholesterol, triglyceride, LDL, and HDL levels of guinea pigs in a 5-week experiment. Serum lipid profile (TC, TG, LDL, and HDL) levels before and after supplementation periods were determined using colorimetric methods. Forty male guinea pigs were divided into two groups. On acclimatization, both groups received a daily dose of pellets (6 g/100 g/day). On weeks 2 and 3, each subjects was fed with minced boiled duck egg yolk and pellets mixture twice a day. Thereafter, groups A and B were given a two-week daily regimen of fish oil (1000 mg) and garlic oil (500mg), respectively, Statistical analysis (paired t-test) revealed significant changes on the serum lipoprotein and cholesterol levels of both groups. Data showed significant increase in TC (t=5.04) and (t=3.61), HDL (t=3.33) and (t=5.24), LDL (=2.80) and (t=2.55), and decrease in TG (t=4.62) and (t=6.62) serum levels of group A and significant decrease in TC (t=12.38) and (t=10.03), TG (t=2.28) and (t=4.16), LDL (t=13.01) and (t=10.10), and increase in HDL (t=2.63) and (t=2.90) serum levels of group B after fish oil and garlic supplementation, respectively. Analysis shows a significant between the effects of fish oil t and garlic oil on TC and LDL levels but there is no significant difference on TG and HDL levels. This research could be deemed as one of the compelling evidences that suggest that garlic oil, which contains allicin, could be an appealing dietary alternative for the management of cardiovascular disease.
Department of Pharmacology
THE M-PHAR nd 0017
A COMPARATIVE STUDY OF THE EFFECTS OF GARLIC AND FISH OILS ON TOTAL CHOLESTEROL, TRIGLYCERIDE, LDL & HDL LEVELS ON MALE GUINEA PIGS (CAVIA PORCELLUS)
The research aims to compare the effects of garlic and fish oil on the cholesterol, triglyceride, LDL, and HDL levels of guinea pigs in a 5-week experiment. Serum lipid profile (TC, TG, LDL, and HDL) levels before and after supplementation periods were determined using colorimetric methods. Forty male guinea pigs were divided into two groups. On acclimatization, both groups received a daily dose of pellets (6 g/100 g/day). On weeks 2 and 3, each subjects was fed with minced boiled duck egg yolk and pellets mixture twice a day. Thereafter, groups A and B were given a two-week daily regimen of fish oil (1000 mg) and garlic oil (500mg), respectively, Statistical analysis (paired t-test) revealed significant changes on the serum lipoprotein and cholesterol levels of both groups. Data showed significant increase in TC (t=5.04) and (t=3.61), HDL (t=3.33) and (t=5.24), LDL (=2.80) and (t=2.55), and decrease in TG (t=4.62) and (t=6.62) serum levels of group A and significant decrease in TC (t=12.38) and (t=10.03), TG (t=2.28) and (t=4.16), LDL (t=13.01) and (t=10.10), and increase in HDL (t=2.63) and (t=2.90) serum levels of group B after fish oil and garlic supplementation, respectively. Analysis shows a significant between the effects of fish oil t and garlic oil on TC and LDL levels but there is no significant difference on TG and HDL levels. This research could be deemed as one of the compelling evidences that suggest that garlic oil, which contains allicin, could be an appealing dietary alternative for the management of cardiovascular disease.
Department of Pharmacology
THE M-PHAR nd 0017
