MARC details
| 000 -LEADER |
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| fixed length control field |
02911nam a22003497a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
PH 2017 0012 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
PILC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20240720152955.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180320b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Language of cataloging |
eng |
| Transcribing agency |
FEU-NRMF MEDICAL LIBRARY |
| Description conventions |
rda |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
english |
| 050 ## - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
PH 2017 0012 |
| 245 ## - TITLE STATEMENT |
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| Title |
Stability of fluconazole solution as an ophthalmic preparation / |
| Statement of responsibility, etc. |
Mari Addylaine M. Reyes, Jonah Jane R. Sedano, Klarisse Pauline M. Taaca, Ruby Jean R. Tumala and Jimrouse Clarisse C. Vinluan. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Fairview, Quezon City: |
| Name of publisher, distributor, etc. |
School of Pharmacy, FEU-NRMF, |
| Date of publication, distribution, etc. |
2017. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
72 pages: |
| Other physical details |
illustrations, tables, photos; |
| Dimensions |
28 cm. + |
| Accompanying material |
CD (soft copy) |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes appendices and bibliographical references. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Abstract: Fungal keratitis is an infection of the cornea. It can cause blindness if not treated and in some cases, treatment cannot restore vision. In these cases, permanent vision impairment or blindness may occur. One treatment for fungal keratitis is fluconazole. In the market, fluconazole is available in oral and intravenous preparations only and there is no ophthalmic preparation available yet. Natamycin 5% w/v is the only ophthalmic preparation registered to the FDA. In some countries in the United States of America, fluconazole is extemporaneously prepared. And there are studies stating the intra-corneal penetration of fluconazole making it a possible formulation for an ophthalmic solution. This led the researchers to study its stability for 30-day period under 40°C ± 2°C. As in-use stability testing (14-day stability)was also performed simulating the usage of the patient in his home under room temperature. Fluconazole (Diflucan) 2 mg/ml was used and was transferred into different vials containing 10 ml each. The purity, pH and viscosity of the solution were determined on day 0 and day 30 of storage for the 30-day stability test. And for the in-use stability test, the purity and pH was determined on day 0, 1, 5, 9 and 14 while the viscosity was determined on day 0, 5, 9 and 14 storage. The researchers therefore conclude that both for the 30-day and 14-stability test, the pH of the solution was within the acceptable range of 4.5 to 11.5, while the assay and viscosity results showed a decreasing value over time because of the solution being subjected to high temperature which enhanced the degradation of the preparation, |
| 521 ## - TARGET AUDIENCE NOTE |
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| Target audience note |
Thesis - School of Pharmacy |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
stability |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
in-use stability |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
fluconazole |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
fungal keratitis |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Reyes, Mari Addylaine M. |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sedano, Jonah Jane R. |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Taaca, Klarisse Pauline M. |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tumala, Ruby Jean R. |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Vinluan, Jimrouse Clarisse C. |
| Relator term |
author |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Room Use |
