MARC details
| 000 -LEADER |
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| fixed length control field |
03595nam a22003617a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
T002874 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
PILC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20241028140417.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
241028b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Language of cataloging |
eng |
| Transcribing agency |
FEU-NRMF MEDICAL LIBRARY |
| Modifying agency |
rda |
| 050 ## - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
MT 2024 0023 c.1 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Angon, Rosh Matthew R |
| Relator term |
author |
| 245 01 - TITLE STATEMENT |
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| Title |
Accuracy of the biomarkers amyloid p-protein (ap), total tau (t-tau), phosphorylated tau (p-tau), and neurofilament chain (NFL) in diagnosing ALZHEIMER'S disease: a systematic review |
| Remainder of title |
[author]: Angon, Rosh Matthew R., Baetiong, Kai Irish D., Del Rosario, Hannah Sophia D.S., Maningding, Jereez Xean J. Manuel, Dainty Jewel C., Mercado, Romulo III D., Quizana, Jezzel Mae G., Santiago, Stephanie Marie G. Saren, Rain Stephanie I., Viray, Jessica Chelsea S. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc. |
Quezon City, Philippines, |
| Name of publisher, distributor, etc. |
FEU-NRMF Dr. Nicanor Reyes Medical Foundation Institute of Medicine, |
| Date of publication, distribution, etc. |
2024 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
73pages |
| Dimensions |
28cm |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes Appendix |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
ABSTRACT:<br/>Early detection of Alzheimer's Disease was challenging due to the lack of reliable biomarkers detect the disease before the onset of symptoms. The study aimed to systematically compare the individual and combined performance, in terms of sensitivity and specificity, of the biomarkers, namely amyloid beta protein (A3), total tau (t-tau), phosphorylated tau (p-tau) and<br/>neurofilament chain (Nfl) in the clinical setting as these are the commonly used hallmarks, except NFL which is new, for diagnosis of AD. The search for scholarly articles was guided by the PRISMA Framework. The risk of bias assessment complied with the Q. UADAS-2 Checklist and that can STATA was used for the forest plot. Of 142 studies initially identified from the databases, 44 studies made it through the quality evaluation. ELISA was the method of detection used by most studies. All individual and combined biomarkers had good to excellent discriminatory ability to diagnose patients with and without AD except for t-tau + NFL. Individually, p-tau is the most reliable biomarker with the highest value of 86 (95% Cl) and the lowest I2 with 63.8 which exhibits low heterogeneity. Among the combinations of biomarkers, the most promising is p-tau + beta amyloid, with an AUC of 92. However, moderate to high heterogeneity together with long ranges of specificity and sensitivity was present in the biomarker’s subgroup, possibly due to the lack of subgroup analysis and by different contexts such as the different use of samples, methodologies and modalities against the reference articles. The findings highlighted the<br/>potential of biomarker combinations to improve the accuracy of diagnosis and risk prediction for the disease but the issue of heterogeneity requires more attention.<br/>KEYWORDS: Alzheimer's Disease (AD), biomarkers, sensitivity\ specificity.<br/> |
| 521 ## - TARGET AUDIENCE NOTE |
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| Target audience note |
School of Medical Technology |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Baetiong, Kai Irish D., |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Del Rosario, Hannah Sophia D.S., |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Maningding, Jereez Xean J. |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Manuel, Dainty Jewel C., |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mercado, Romulo III D., |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Quizana, Jezzel Mae G., |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Santiago, Stephanie Marie G. |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Saren, Rain Stephanie I |
| Relator term |
author |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Viray, Jessica Chelsea S. |
| Relator term |
author |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Enable Ebook |
Yes |
| Text to speech |
No |
| Electronic format type |
pdf |
| Uniform Resource Identifier |
<a href="https://library.feu-nrmf.ph/cgi-bin/koha/opac-retrieve-file.pl?id=655ea3e1f88927577bd1587681269c30">https://library.feu-nrmf.ph/cgi-bin/koha/opac-retrieve-file.pl?id=655ea3e1f88927577bd1587681269c30</a> |
| Link text |
Click here for FULL TEXT |
| Permission |
ALL |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Theses |
