A Comparative Study on the Hypoglycemic Activity of the Aqueous Extracts of Syzygium cumini Linne ( Myrtaceae) and Psidium guajava Linne (Myrtaceae) on Alloxan- Induced Diabetic Rattus novergicus (Record no. 8260)
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fixed length control field | 02260nam a22002297a 4500 |
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control field | 6332 |
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control field | PILC |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20240720152622.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 160505b2007 xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Transcribing agency | FEU-NRMF MEDICAL LIBRARY |
041 ## - LANGUAGE CODE | |
Language code of text/sound track or separate title | English |
050 ## - LIBRARY OF CONGRESS CALL NUMBER | |
Classification number | RES S MED BIO 2007 0001 |
100 ## - MAIN ENTRY--PERSONAL NAME | |
Personal name | 1st year Medicine Section B2 |
245 ## - TITLE STATEMENT | |
Title | A Comparative Study on the Hypoglycemic Activity of the Aqueous Extracts of Syzygium cumini Linne ( Myrtaceae) and Psidium guajava Linne (Myrtaceae) on Alloxan- Induced Diabetic Rattus novergicus |
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
Date of production, publication, distribution, manufacture, or copyright notice | 2007 |
336 ## - CONTENT TYPE | |
Content type term | Text |
337 ## - MEDIA TYPE | |
Media type term | unmediated |
338 ## - CARRIER TYPE | |
Carrier type term | Volume |
502 ## - DISSERTATION NOTE | |
Degree type | Medicine |
Miscellaneous information | Research project |
520 ## - SUMMARY, ETC. | |
Summary, etc. | The primary purpose of this study is to identify the general compounds present in Syzygium cumini (duhat) and Psidium guajava (guava) and to compare their hypoglycemic activity. Phytochemical screening was done to identify and to compare the general compound in both samples. The presence of tannins, glycosides, saponins and reducing substances were identified in both guava and duhat samples. On the other hand, plant acids, alkaloids and flavones were noted to be absent for both samples. Pre-clinical study was done using 40 male rats (Rattus novergicus) weighing 108-205 grams and all were randomly assigned to four different groups (10 per group): Group 1 water (negative control), group 2 Duhat Test solution (250 mg/kg), Group 3 Guava test solution (250mg/kg) and Group 4 Glibenclamide (positive control -3mg/kg). Induction of diabetes was done using alloxan monohydrate with a single dose 1000 mg/kg administered orally. Rats with significant increase in serum glocuse level after a week to the baseline equal or greater than 150-300 mg/dl were considered diabetic. After one hour of oral administration the mean decrease in FBS levels of the four groups was not statistically significant. However, after two hours it became significant. The study suggests that duhat (250g mg/kg) and guava (250 mg/kg) can significantly lower blood glucose level in experimental rats after two hours of oral administration. Their hypoglycemic activities were found to be equal. It can be said that these two samples can be possible sources of lead compounds. |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | Library of Congress Classification |
Koha item type | Research |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
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Library of Congress Classification | Far Eastern University - Nicanor Reyes Medical Foundation | Far Eastern University - Nicanor Reyes Medical Foundation | Research | 01/14/2016 | SMEDBIO20070001 | R000443 | 03/04/2016 | 07/22/2016 | Research |