MARC details
| 000 -LEADER |
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| fixed length control field |
03114nam a22002537a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
M PHAR 2012 0008 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
PILC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20240720152753.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160505b2012 xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Language of cataloging |
eng |
| Transcribing agency |
FEU-NRMF MEDICAL LIBRARY |
| Description conventions |
rda |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
english |
| 050 ## - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
M PHAR 2012 0008 |
| 245 ## - TITLE STATEMENT |
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| Title |
Acute oral toxicity of euphorbia hirta linn (tawa-tawa) in sprague dawley rats / |
| Statement of responsibility, etc. |
Section F. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc. |
Farview, Quezon City: |
| Name of publisher, distributor, etc. |
Department of Pharmacology, FEU-NRMF, |
| Date of publication, distribution, etc. |
2012. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
51 pages: |
| Other physical details |
illustrations, tables, photos; |
| Dimensions |
28 cm. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Source |
rdacarrier |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes appendices and bibliographical references. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Abstract: he objective of the study are to determine the lethal dose ( LD50 ) of Euphorbia hirta L. lyophilized extract on Sprague- Dawley rats, Second, the researchers describe the acute toxidrome of Euphobia hirta L. (tawa-tawa) based on the changes in central nervous, respiratory, autonomic, eyes, ears behavior and weight. Third, is to describe the gross and histolopathologic changes in Sprague Dawley rats in 3 days brought about by Euphorbia hirta L. The study used the Fixed Dose Procedure and Quasi-Experimental design. The leaves, stem, flower were subjected to decoction, a process where in the leaves where extracted by boiling. After decoction, it was lyophilized to obtain powdered from the water-soluble components. The subjects were randomly chosen, one rat was used for the sighting study and five rats were used for the main study. The dose for the sighting study was 300mg/kg body weight and used 2000mg/kg body weight for the main study. The lyophilized Tawa-Tawa extract was tested on laboratory experimental rats and was given single dose via lavage. There were no, incidence (0%) central nervous depression, on the other hand there were 100% increase in the respiratory rate and startle response, only 20% exhibited fine and course body tremors. Furthermore, only 20% exhibited changes in the eyes, there were no significant findings in the ears, in automatic changes, 20% exhibited salivation and 1005 exhibited tail lashing, pilo motor erection and increase body temperature. For behavioral changes 100% exhibited passivity and there were also an increased body weight with an average of 0.6 grams. The researchers conclude that the LD50 of Euphorbia hirta L. (Tawa-Tawa) is greater than 2000mg/kg/bw. The extract has no significant toxic effect on the central nervous system, respiratory system, autonomic nervous system, general appearance of the eyes & ears, body weight and behaviour of Sprague Dawley rats. Also, the researchers conclude that there are no gross abnormality in the organs of Sprague Dawley rats including, heart, lungs, liver kidneys, spleen, as well as in the small and large intestines. Lastly, the histopathologic results are not sufficient to conclude that there is no toxicity at a dose of 2000mg/kg/bodyweight due to poor specimen quality. |
| 521 ## - TARGET AUDIENCE NOTE |
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| Target audience note |
Thesis - Department of Pharmacology |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Section 2F |
| Relator term |
author |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Room Use |
