"Epstein barr virus-associated hemophagocytic lymphohistiocytosis" / Hannah M. Reandelar.

By:

Reandelar, Hannah M., MD [author]

Language: English Publication details: Fairview, Quezon City Department of Child Health, FEU-NRMF, 2016Description: (in folder)Content type:

text

Media type:

unmediated

Carrier type:

volume

LOC classification:

CH20160003

Summary: ABSTRACT: Hemophagocytic Lymphohistiocytosis (HLH) is the aggressive proliferation of activated macrophages and histiocytes, which phagocytose RBCs, WBCs, and platelets leading to the clinical symptoms. Incidence is reported to be 1.2 cases per million persons per year. However, unpublished observations estimate that the figures have slightly increased over time because of improved detection. This is a case of 5-year old female who presented with intermittent fever for one and a half month, who was initially treated as dengue hemorrhagic fever. However, due to the persistence of fever and concomitant pancytopenia, other differential diagnoses such as Leukemia, and Systematic Lupus Erythematosus were considered. On her second month of illness, she was finally diagnosed with HLH secondary to Epstein Barr virus infection. In the sad turn of events, the patient succumbed to the complications of HLH. This report, therefore, aims to discuss the clinical presentation and diagnosis of HLH, and why it should be considered as an important diagnosis consideration in patients who present prolonged fever. Treatment and prognosis will also be discussed.

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Item type	Current library	Call number	Status	Date due	Barcode
Research	Far Eastern University - Nicanor Reyes Medical Foundation Research	CH20160003 (Browse shelf(Opens below))	Available		R000499

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Previous	CH 2015 0009 Wolf-hirschhorn syndrome 46, xx, del (4) (p15.2) : a break that can't be made whole /	CH20160001 "Catch-ing digeorge at 22" a case report of a neonate considered with digeorge syndrome /	CH20160002 "If all else fails" refractory kawasaki disease a case report /	CH20160003 "Epstein barr virus-associated hemophagocytic lymphohistiocytosis" /	CH20160004 "SRH: it's not that simple!" a case report of a 16-year old with henoch schonlein purpura (HSP) who developed spontaneous renal hematoma (SRH) /	CH20160005 "Yellow fellow" immune hemolytic anemia secondary to dengue hemorrhagic fever a case report /	CH20170001 A Rare case of an adolescent with an ovarian new growth "beyond the tummy-ache" /	Next

Includes bibliographical references.

ABSTRACT: Hemophagocytic Lymphohistiocytosis (HLH) is the aggressive proliferation of activated macrophages and histiocytes, which phagocytose RBCs, WBCs, and platelets leading to the clinical symptoms. Incidence is reported to be 1.2 cases per million persons per year. However, unpublished observations estimate that the figures have slightly increased over time because of improved detection. This is a case of 5-year old female who presented with intermittent fever for one and a half month, who was initially treated as dengue hemorrhagic fever. However, due to the persistence of fever and concomitant pancytopenia, other differential diagnoses such as Leukemia, and Systematic Lupus Erythematosus were considered. On her second month of illness, she was finally diagnosed with HLH secondary to Epstein Barr virus infection. In the sad turn of events, the patient succumbed to the complications of HLH. This report, therefore, aims to discuss the clinical presentation and diagnosis of HLH, and why it should be considered as an important diagnosis consideration in patients who present prolonged fever. Treatment and prognosis will also be discussed.

Research - Department of Child Health

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