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A Rare case of an 8 year old male with chronic inflammatory demyelinating polyneuropathy "swept me off my feet" / Ma. Chariza D.Tantamco.

By: Language: English Publication details: Fairview, Quezon City Department of Child Health, FEU-NRMF, 2018Description: (in folder)Content type:
  • rdacontent
Media type:
  • rdamedia
Carrier type:
  • rdacarrier
LOC classification:
  • CH20180003
Summary: ABSTRACT: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is the most common treatable chronic neuropathy worldwide. CIDP typically presents with chronic, progressive, stepwise progressive or relapsing weakness with associated sensory symptoms, which develops over at least an 8-week period. This is a case of an 8 year old male who presented with myalgia and weakness of the lower extremities. Chronic Inflammatory Demyelinating Polyneuropathy was considered based on the ascending progression of weakness from the lower extremities up to the bulbar involvement causing dysphagia, progressive respiratory muscle weakness that warranted mechanical ventilation, facial weakness and autonomic symptoms such as blood pressure instability, cardiac arrhythmia and urinary retention. The most important laboratory studies that support of the diagnosis of CIDP are the cerebrospinal fluid (CSF) examination and nerve biopsy. The CSF evaluation is the most sensitive as protein is elevated in up to 94% of cases with normal white cells. Spinal Fluid albuminocytological dissociation supports the diagnosis of CIDP. He was started with 2g/kg of intravenous immunoglobulin (IVIG) over 5 days.
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Includes appendix and bibliographical references.

ABSTRACT: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is the most common treatable chronic neuropathy worldwide. CIDP typically presents with chronic, progressive, stepwise progressive or relapsing weakness with associated sensory symptoms, which develops over at least an 8-week period. This is a case of an 8 year old male who presented with myalgia and weakness of the lower extremities. Chronic Inflammatory Demyelinating Polyneuropathy was considered based on the ascending progression of weakness from the lower extremities up to the bulbar involvement causing dysphagia, progressive respiratory muscle weakness that warranted mechanical ventilation, facial weakness and autonomic symptoms such as blood pressure instability, cardiac arrhythmia and urinary retention. The most important laboratory studies that support of the diagnosis of CIDP are the cerebrospinal fluid (CSF) examination and nerve biopsy. The CSF evaluation is the most sensitive as protein is elevated in up to 94% of cases with normal white cells. Spinal Fluid albuminocytological dissociation supports the diagnosis of CIDP. He was started with 2g/kg of intravenous immunoglobulin (IVIG) over 5 days.

Research - Department of Child Health

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