Undifferentiated uterine sarcoma : a case report and review of diagnostic methods / Jan Paulo S. Pereira, Robert Glen R. Abesamis and Mari Karr A. Esguerra.

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Language: english Publication details: Fairview, Quezon City: Department of Pathology, FEU-NRMF, 2020.Description: illustrations, tables, photos; (in folder) with flash drive (soft copy)Content type:

text

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unmediated

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volume

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LOC classification:

PATH 2020 0003

Summary: Abstract: Undifferentiated uterine sarcoma (UUS) is an extremely rare and notoriously aggressive form of endometrial stromal sarcomas (ESS) described to have high grade cytologic features without a specific type of differentiation. Outcome is very poor and its pathogenesis is currently unknown. Its low incidence limits its studies resulting to scarce amount of information both locally and internationally. It represents a diagnosis of exclusion making it both a clinical and a diagnostic dilemma. Therefore, arriving at an early diagnosis is extremely difficult. This case report aims to discuss UUS as a pathologic entity, review the utility of immunohistochemistry (IHC) when dealing with poorly differentiated uterine tumors, and briefly discuss molecular techniques used to diagnose this entity. We describe the case of a 69-year-old woman who presented with postmenopausal bleeding who subsequently underwent dilation and curettage. Her surgical pathology report revealed a poorly differentiated neoplasm with the following considerations but not limited to: high grade serous carcinoma, clear cell carcinoma, endometrial stromal sarcoma, and leiomyosarcoma. The patient, then, underwent extrafascial hysterectomy with bilateral salphingooophorectomy and bilateral lymph node dissection. Histomorphologic features revealed a poorly copy differentiated malignant tumor suggestive of underwent uterine sarcoma. An IHCpanel (ER, PR, cytokeratin, h-caldesmon, desmin, vimentin, CD10 and cyclin-D1) were them employed ultimately confirming the diagnosis of undifferentiated uterine sarcoma by eliminating other malignant conditions that mimic its histomorphologic gestures. By reporting this case, additional information will be added up to the already limited amount of studies found in the literature.

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Holdings
Item type	Current library	Call number	Status	Notes	Date due	Barcode
Room Use	Far Eastern University - Nicanor Reyes Medical Foundation Research	PATH 2020 0003 (Browse shelf(Opens below))	Available	with flash drive (soft copy)		R000995

Includes appendices and bibliographical references.

Abstract: Undifferentiated uterine sarcoma (UUS) is an extremely rare and notoriously aggressive form of endometrial stromal sarcomas (ESS) described to have high grade cytologic features without a specific type of differentiation. Outcome is very poor and its pathogenesis is currently unknown. Its low incidence limits its studies resulting to scarce amount of information both locally and internationally. It represents a diagnosis of exclusion making it both a clinical and a diagnostic dilemma. Therefore, arriving at an early diagnosis is extremely difficult. This case report aims to discuss UUS as a pathologic entity, review the utility of immunohistochemistry (IHC) when dealing with poorly differentiated uterine tumors, and briefly discuss molecular techniques used to diagnose this entity. We describe the case of a 69-year-old woman who presented with postmenopausal bleeding who subsequently underwent dilation and curettage. Her surgical pathology report revealed a poorly differentiated neoplasm with the following considerations but not limited to: high grade serous carcinoma, clear cell carcinoma, endometrial stromal sarcoma, and leiomyosarcoma. The patient, then, underwent extrafascial hysterectomy with bilateral salphingooophorectomy and bilateral lymph node dissection. Histomorphologic features revealed a poorly copy differentiated malignant tumor suggestive of underwent uterine sarcoma. An IHCpanel (ER, PR, cytokeratin, h-caldesmon, desmin, vimentin, CD10 and cyclin-D1) were them employed ultimately confirming the diagnosis of undifferentiated uterine sarcoma by eliminating other malignant conditions that mimic its histomorphologic gestures. By reporting this case, additional information will be added up to the already limited amount of studies found in the literature.

Research - Department of Pathology & Laboratory Diagnosis

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