Un-dress me : a 7 year old female with drug reaction and systemic symptoms with anti-koch's medications / Judith Marie D. Gregorio and Ma. Theresa Policarpio.

Contributor(s):

Language: english Publication details: Fairview, Quezon City: Department of Child Health, FEU-NRMF, 2020.Description: (in folder) with CD (soft copy)Content type:

text

Media type:

unmediated

Carrier type:

volume

LOC classification:

CH 2020 0005

Summary: Abstract: Drug Reaction with eosinophilia and systemic is usually seen after initial exposure to an anticonvulsant or other drugs such as allopurinol, sulfonamides. 1 case was documented from the past 5 years while 32 cases from the past 10 years in the National Capital Region of the Philippines. However, there are only few reported cases attributed to anti-Koch's medications. This usually presents with the triad of fever, rash and hapatitis. Mortality from complications such as nephritis, pneumonitis, myocarditis, shock and encephalitis approaches 10%. This is a case of DRESS in a 7-year-old female who lives in Quezon City, Philippines with known primary pulmonary tuberculosis and currently on her 2nd month of treatment maintained on rifampicin, isoniazid and pyrazinamide. She presented with a generalized erythematous to violaceous rash, headache, cough, vomiting, loose stools, abdominal pain and difficulty of breathing. Physical examination showed generalized urticarial rashes with some erythematous and some violaceous lesions that blanch on pressure. Shewas first diagnosed as to consider Measles due to the presentation of the rashes. Work up showed eosinophilia, elevated liver enzymes and pleural effusion. She was the diagnosed as a case of drug reaction with eosinophilia and systemic symptoms. After 1 week of discontinuation of rifampicin, isoniazid and pyrazinamide, rashes resolved and laboratories became normal. DRESS is considered if there is a rash that is accompanied with eosinophilia and other systemic symptoms. Primary therapeutic intervention is withdrawal of the medication. Patient resumed intake of previous anti-Koch's medications with ethambutol. This case report promotes awareness on how to diagnose and manage patients with Primary Pulmonary Tuberculosis who had systemic reactions with anti-Koch's medications.

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Holdings
Item type	Current library	Call number	Status	Notes	Date due	Barcode
Room Use	Far Eastern University - Nicanor Reyes Medical Foundation Research	CH 2020 0005 (Browse shelf(Opens below))	Available	with CD (soft copy)		R000968

Includes appendices and bibliographical references.

Abstract: Drug Reaction with eosinophilia and systemic is usually seen after initial exposure to an anticonvulsant or other drugs such as allopurinol, sulfonamides. 1 case was documented from the past 5 years while 32 cases from the past 10 years in the National Capital Region of the Philippines. However, there are only few reported cases attributed to anti-Koch's medications. This usually presents with the triad of fever, rash and hapatitis. Mortality from complications such as nephritis, pneumonitis, myocarditis, shock and encephalitis approaches 10%. This is a case of DRESS in a 7-year-old female who lives in Quezon City, Philippines with known primary pulmonary tuberculosis and currently on her 2nd month of treatment maintained on rifampicin, isoniazid and pyrazinamide. She presented with a generalized erythematous to violaceous rash, headache, cough, vomiting, loose stools, abdominal pain and difficulty of breathing. Physical examination showed generalized urticarial rashes with some erythematous and some violaceous lesions that blanch on pressure. Shewas first diagnosed as to consider Measles due to the presentation of the rashes. Work up showed eosinophilia, elevated liver enzymes and pleural effusion. She was the diagnosed as a case of drug reaction with eosinophilia and systemic symptoms. After 1 week of discontinuation of rifampicin, isoniazid and pyrazinamide, rashes resolved and laboratories became normal. DRESS is considered if there is a rash that is accompanied with eosinophilia and other systemic symptoms. Primary therapeutic intervention is withdrawal of the medication. Patient resumed intake of previous anti-Koch's medications with ethambutol. This case report promotes awareness on how to diagnose and manage patients with Primary Pulmonary Tuberculosis who had systemic reactions with anti-Koch's medications.

Research - Department of Child Health

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