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Lymphocyte immunotherapy in recurrent pregnancy loss : a case report / Joana Jo R. Ludovica.

Contributor(s): Language: english Publication details: Fairview, Quezon City: Department of Obstetrics and Gynecology, FEU-NRMF, 2021.Description: 25 pages: photos; (in folder) + with flash drive (soft copy)Content type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
Subject(s): LOC classification:
  • OB 2021 0006
Summary: Abstract: Recurrent Pregnancy Loss (RPL) is a multifactorial condition defined as having two or more consecutive pregnancy losses. Investigation of the well-established causes is warranted to increase the chance of subsequent good pregnancy outcome. However, 50% of the RPL cases remains unexplained. Pregnancy involves shift in the immunologic response to initiate immune tolerance. Deviation from the normal immune tolerance response may lead to pregnancy failure and is the proposed mechanism of unexplained recurrent pregnancy loss. Lymphocyte immunotherapy, which involves transfusion of paternal leukocytes to the maternal peripheral blood to induce an immune response creating a conducive environment for pregnancy maintenance, is a proposed therapy for unexplained RPL. This is a case report of a 40 year old, Gravida 7 Para 1, with Recurrent Pregnancy Loss, with no known genetic, uterine, and coagulation anomalies who initially underwent assisted reproductive techniques with Intrauterine Insemination and eventually underwent 4 cycles of Lymphocyte Immunotheraphy, and was able to conceive and deliver at term.
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Item type Current library Call number Status Notes Date due Barcode
Room Use Far Eastern University - Nicanor Reyes Medical Foundation Research OB 2021 0006 (Browse shelf(Opens below)) Available with flash drive (soft copy) R000893
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OB 2021 0003 Association of fetal abdominal circumference with capillary blood glucose levels and perinatal outcome among women with gestational diabetes mellitus / OB 2021 0004 A Comparison of the efficacy of single dose cefazolin versus single dose cefazolin plus 7-day mupirocin ointment wound application in preventing surgical site infection among patients undergoing major obstetric and gynecologic procedures at a tertiary university hospital : a two-year single blinded randomized controlled trial / OB 2021 0005 A Randomized controlled trial comparing the efficacy of a seven day regimen of co-amoxiclav versus a single dose second generation cephalosporin (cefoxitin) as prophylactic antibiotic therapy for third and fourth degree perineal lacerations among post-partum patients in a tertiary medical center / OB 2021 0006 Lymphocyte immunotherapy in recurrent pregnancy loss : a case report / OB 2021 0007 "The Missing X" - profile of a 25-year old with turner syndrome : a case report / OB 2022 0001 Postabortal bleeding and endometrial cancer : a diagnostic dilemma / OB 2022 0002 Prevalence of the different phenotypes of polycystic ovarian syndrome in adolescents and its association to metabolic and cardiovascular risk

Includes appendices and bibliographical references.

Abstract: Recurrent Pregnancy Loss (RPL) is a multifactorial condition defined as having two or more consecutive pregnancy losses. Investigation of the well-established causes is warranted to increase the chance of subsequent good pregnancy outcome. However, 50% of the RPL cases remains unexplained. Pregnancy involves shift in the immunologic response to initiate immune tolerance. Deviation from the normal immune tolerance response may lead to pregnancy failure and is the proposed mechanism of unexplained recurrent pregnancy loss. Lymphocyte immunotherapy, which involves transfusion of paternal leukocytes to the maternal peripheral blood to induce an immune response creating a conducive environment for pregnancy maintenance, is a proposed therapy for unexplained RPL. This is a case report of a 40 year old, Gravida 7 Para 1, with Recurrent Pregnancy Loss, with no known genetic, uterine, and coagulation anomalies who initially underwent assisted reproductive techniques with Intrauterine Insemination and eventually underwent 4 cycles of Lymphocyte Immunotheraphy, and was able to conceive and deliver at term.

Research - Department of Obstetrics & Gynecology

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